磁共振扩散张量成像在大鼠C6脑胶质瘤分级中的应用研究

Application of magnetic resonance diffusion tensor imaging in rat C6 glioma grading

目的探讨磁共振扩散张量成像(DTI)参数部分各向异性分数(FA)值在大鼠脑胶质瘤分级中的应用价值。方法67只雌性Wistar大鼠按照随机数字表法分成实验组57只,对照组10只,所有成活大鼠分别在接种后第1~2周(22只)和3~4周(35只)行3.0TDTI检查,获得瘤体FA值,并与病理结果对照。结果 57只荷瘤大鼠,其中低级别胶质瘤18只,高级别胶质瘤39只,DTI显示高级别胶质瘤瘤体FA值(0.167±0.035)高于低级别胶质瘤(0.147±0.015),差异有统计学意义(t=2.34,P<0.05)。结论 DTI参数FA值可以为术前胶质瘤分级提供准确可靠、无创的影像学信息。

Objective To explore the application value of fractional anisotropy(FA)values of magnetic resonance diffusion tensor imaging(DTI)parameters in rat rat glioma grading.Methods Sixty-seven female Wistar rats were divided into the experimental group(n=57)and control group(n=10)according to the random number table method.All the surviving rats were examined by 3.0T DTI at 1-2 weeks(22 cases)and 3-4 weeks(35 cases)after inoculation,and the FA values of the tumor were obtained and compared with the pathological results.Results Among 57 tumor-loading rats,there were 18 low-grade gliomas and 39 high-grade gliomas.DTI showed that the FA value of high-grade gliomas was higher than that of the low-grade glioma,the difference was statistically significant[(0.167±0.035)vs.(0.147±0.015),t=2.34,P<0.05].Conclusion The FA value of DTI parameters can provide accurate,reliable and noninvasive imaging information for preoperative glioma grading.