介入支架治疗脑梗塞临床疗效及对患者纤溶系统影响研究

Interventional stent therapy in patients with cerebral infarction clinical curative effect and the effect of the fibrinolytic system analysis

目的:研究分析介入支架治疗脑梗塞患者的临床疗效及对纤溶系统的影响。方法:选取脑梗塞患者84例,根据治疗方式分为观察组和对照组各42例。对照组采用阿托伐他汀治疗,观察组则予以介入支架治疗。分别比较两组临床疗效,治疗前后血浆tPA与PAI-1水平变化情况,治疗前后神经功能以及日常生活活动能力变化情况。结果:观察组治疗总有效率95.24%(40/42),高于对照组80.95%(34/42),差异具有统计学意义(P<0.05)。观察组治疗后血浆tPA与PAI-1水平分别为(10.4±3.1)ng/ml、(54.3±23.2)ng/ml,均低于对照组的(12.7±3.3)ng/ml、(66.9±22.7)ng/ml,差异均有统计学意义(P均<0.05)。两组治疗后NIHSS评分均低于治疗前,而观察组又低于对照组,差异均有统计学意义(P均<0.05)。两组治疗后Barthel指数均高于治疗前,而观察组又高于对照组,差异均有统计学意义(P均<0.05)。结论:血管介入支架治疗脑梗塞的临床疗效显著,可有效改善患者纤溶系统,促进神经功能的恢复,同时显著提高患者日常生活活动能力。

Objective:To study the clinical curative effect of interventional stent therapy in patients with cerebral infarction and the impact on the fibrinolytic system analysis.Methods:Selected 84 cases of cerebral infarction patients.According to the different methods of treatment were divided into observation group and control group each had 42 cases.The control group was using atorvastatin therapy,observation group was involved in stents.Respectively compared two groups of clinical curative effect,before and after treatment plasma tPA and PAI 1 level,the changes of neural function before and after the treatment,and daily life activities ability changes.Results:The observation group treatment the total effective rate was 95.24%(40/42),higher than that of control group 80.95%(34/42),with significant difference(P<0.05).Observation group after treatment serum tPA and PAI 1 level respectively(10.4±3.1)ng/ml,(54.3±23.2)ng/ml,were lower than the control group(12.7±3.3)ng/ml,(66.9±22.7)ng/ml,all had significant differences(P<0.05).NIHSS score of the two groups after treatment than before treatment,the observation group was lower than the control group,had significant differences(P<0.05).Barthel index of the two groups after treatment were higher than before the treatment,the observation group was higher than that of control group,and were significant differences(P<0.05).Conclusion:Vascular interventional stent in the treatment of cerebral infarction clinical curative effect is distinct,can effectively improve the patients fibrinolytic system,promote the recovery of neural function,at the same time significantly improve the ability of patients daily life activities.