肿瘤坏死因子与子宫内膜异位症相关性研究

Effect of tumor necrosis factor on endometriosis

目的:探讨肿瘤坏死因子TNF-α、TNF-β与子宫内膜异位症的相关性。方法:选取子宫内膜异位症患者87例作为研究组,将同期体检结果健康的女性92例作为对照组。分别检测两组血清肿瘤坏死因子(TNF-α、TNF-β)水平,并进行相关性分析。结果:研究组TNF-α、TNF-β水平与对照组比较明显增高,差异有统计学意义(P<0.05);研究组Ⅲ~Ⅳ期TNF-α、TNF-β水平明显高于Ⅰ~Ⅱ期,P<0.05;两组分泌期、增生期分别比较,P<0.05;分泌期与增生期组内比较,差异无统计学意义(P>0.05);实验组患者术后与术前比较,TNF-α、TNF-β水平均明显降低(P<0.05);Ⅲ~Ⅳ期患者术后与术前比较,TNF-α、TNF-β水平下降更明显(P<0.001);EMT患者血清TNF-α、TNF-β与AFS-r评分呈直线相关(r值分别为0.88、0.76,P均<0.05)。结论:子宫内膜异位症患者血清肿瘤坏死因子水平明显增高,术后血清肿瘤坏死因子水平明显降低,其血清水平与病变程度有一定相关性。

Objective:To investigate the relationship between tumor necrosis factor TNF-αand endometriosis.Methods:87 cases of endometriosis patients was experimental group,the results of physical examination in the same period,92 cases of healthy women was the control group.serum tumor necrosis factor(TNF-α,TNF-β)levels were detected in two groups and analysis.Results:The levels of TNF-αand TNF-βin experimental group were compared with those in control group,Significant difference(P<0.05);The level of TNF-αand TNF-βin the experimental group was significantly higher than that in the I^II phase in the experimental group(III^IV),P<0.05;Two groups of secretory phase,proliferative phase were compared,P<0.05;Comparison of secretory phase and proliferative phase,no obvious difference P>0.05;compared with before treatment,the levels of TNF-αand TNF-βwere significantly decreased in the experimental group(P<0.05);patients with stage III^IV were compared with those before operation,TNF-α,TNF-βbeta levels decreased more significantly(P<0.001);Serum TNF-α,TNF-βbeta and afs-r score in patients with EMT showed linear correlation,P<0.05(r values were 0.88,0.76).Conclusion:The level of serum tumor necrosis factor is significantly higher in patients with endometriosis,serum tumor necrosis factor levels are significantly decreased after operation,there is a correlation between the serum level and the severity of the disease.