HE_4、CA_(125)和D-dimer检测在卵巢癌早期诊断筛查中的应用价值

Application value of HE_4,CA_(125) and D-dimer in early diagnosis of ovarian cancer

目的:探讨HE_4、CA_(125)和D-dimer在卵巢癌早期诊断筛查中的应用价值。方法:选择卵巢癌患者69例(卵巢癌组),良性卵巢囊肿患者65例(良性组),另外选择健康体检女性63例(健康组),分别监测三组的血清指标HE_4、CA_(125)和D-dimer,分析单项及联合检测的诊断效能。结果:卵巢癌组的HE_4、CA_(125)和D-dimer水平显著高于良性组和健康组(P<0.05),良性组的HE_4水平显著高于健康组(P<0.05),良性组和健康组的CA_(125)和D-dimer水平比较差异无统计学意义(P>0.05)。CA_(125)+HE_4联合检测的敏感度90.31%,高于HE 488.93%,CA_(125)73.71%以及D-dimer64.89%,而CA_(125)+HE_4+D-dimer联合检测的敏感度94.87%,不仅高于三项单独检测,还高于CA_(125)+HE_4联合检测90.31%。结论:血清指标HE_4、CA_(125)和D-dimer联合检测可提高卵巢癌早期筛查的准确度,从而提高诊断准确率,对卵巢癌的早期治疗及预后非常有重要意义。

Objective:To investigate the value of HE4,CA 125 and D-dimer in early diagnosis of ovarian cancer.Methods:69 cases of patients with ovarian cancer(ovarian cancer group),65 cases of benign ovarian cyst patients(benign group),another 63 cases of healthy women(healthy group),three groups of members of the serum HE 4,CA 125 and D-dimer were compared,and analysis of diagnostic efficacy of single or combined detection of.Results:the ovarian cancer group HE 4,CA 125 and D-dimer levels were significantly higher than benign group and healthy group(P<0.05),benign group the level of HE 4 was significantly higher than that of the control group(P<0.05),no statistical significance in benign group and healthy group of CA 125 and D-dimer level difference(P>0.05).The combined detection sensitivity of CAI 125+HE 4 was 90.31%,higher than the HE 4 88.93%,CA 125 73.71%and D-dimer 64.89%,and the combined detection sensitivity of CAI 125+HE 4+D-dimer was 94.87%,three was not only higher than the single detection,combined detection of CAI 125+HE 4 is higher than 90.31%.Conclusion:the combined detection of serum HE 4,CA 125 and D-dimer can improve the accuracy of early screening for ovarian cancer,so as to improve the accuracy of diagnosis,which is of great significance for the early treatment and prognosis of ovarian cancer.