干燥综合征患者血液系统受损与自身抗体相关性研究

Correlation between blood system impairment and autoantibodies in patients with primary Sjogren's syndrome

目的分析原发性干燥综合征(primary Sjogren’s syndrome,p SS)患者血液系统损害与其自身抗体之间有无相关性。方法选取住院p SS患者65例,均记录血液分析、抗SSA抗体、抗SSB抗体、类风湿因子(rheumatoid factors,RF)、抗核抗体(antinuclearantibody,ANA)等,并进一步探讨血液系统受损与自身抗体表达的关系。结果 65例患者中,ANA阳性53例(81.5%),RF阳性16例(24.6%),抗SSA抗体阳性17例(26.3%),抗SSB阳性19例(18.5%),唇腺活检阳性65例(100%)。合并血液系统受损组患者18例(27.7%),其中贫血11例(16.9%),白细胞减少10例(15.4%),血小板减少4例(6.2%);血液分析中仅一系减少13例(20%),两系减少3例(4.6%),三系减少2例(3.1%)。血液系统受损组患者血液中抗SSA抗体阳性率为44.4%,明显高于无血液系统受损组的19.1%(P=0.038),2组间RF、ANA、抗SSB抗体水平差异无统计学意义(P>0.05)。结论 p SS患者容易合并血液系统受损,且其与抗SSA抗体具有一定相关性。

Objective To investigate the correlation between blood system impairment and autoantibodies in patients with primary Sjogren’s syndrome(pSS).Methods A total of 65 patients with pSS who were admitted and treated in our hospital were enrolled in the study,in whom,there were 56 females and 9 males,and patient’s age range was 33~78 years,with an average age being(54.31±10.36)years.The duration of the disease was from 1 month to 15 years,with an average duration being(5.34±3.76)years.All the patients were excluded from the other rheumatic diseases,hematological diseases and infectious diseases.The patient’s age,sex,course of disease and previous history were recorded.The blood analysis anti SSA antibody,anti SSB antibody,anti nuclear antibody(ANA),rheumatoid factors(RF)were analyzed to explore the correlation between blood system impairment and autoantibodies in patients with primary Sjogren’s syndrome.Results Among the 65 patients,53 cases(81.5%)were positive for ANA,16 cases(24.6%)were positive for RF,17 cases(26.3%)were positive for SSA,19 cases(18.5%)were positive for SSB,65 cases(100%)were positive for labial gland biopsy.Moreover 18 cases(27.7%)were complicated by blood system impairment,including 11 cases(16.9%)of anemia,10 cases(15.4%)of leukopenia and 4 cases(6.2%)of thrombocytopenia.According to blood analysis,13 cases(20%)were decreased in single aspects,3 cases(4.6%)were decreased in two aspects and 2 cases(3.1%)were decreased in three aspects.The positive rate of SSA in patients with blood system impairment was 44.4%,which was significantly higher than that in patients without blood system impairment(P<0.05).However there were no significant differences in the levels of RF,ANA and SSB between the two groups.Conclusion The patients with pSS are commonly complicated by blood system impairment,moreover,SSA may be correlated with blood system impairment at some extent.