阿托伐他汀对急性心肌梗死患者血脂、MMP-9水平和心功能的影响及疗效分析

Effect of Atorvastatin on Blood Lipid Levels,MMP-9 Levels and Cardiac Function in Patients with Acute Myocardial Infarction

目的分析阿托伐他汀对急性心肌梗死患者血脂、金属基质蛋白9(MMP-9)水平和心功能的影响及治疗效果。方法选取2014年2月-2016年9月我院收治的急性心肌梗死患者124例,根据治疗方法不同分为对照组和观察组,各62例。对照组患者采用常规治疗,观察组在常规治疗基础上联合阿托伐他汀治疗,比较两组患者的治疗效果。结果治疗后,两组患者血脂指标(TG、TC、LDL-C)和心功能指标(LVEDD、IVST)水平较治疗前下降,HDL-C、LVEF水平较治疗前上升;观察组患者血脂指标和心功能水平均优于对照组(P<0.05)。治疗后,两组患者的CD63、CD62P、ET、MMP-9、CD40L及H-FABP水平均较治疗前下降;观察组患者CD63、CD62P、ET、MMP-9、CD40L及H-FABP水平均低于对照组(P<0.05)。结论阿托伐他汀治疗急性心肌梗死可有效改善患者血脂、心功能和内皮功能水平,抑制血小板活化,稳定斑块。

Objective To analyze the effect of atorvastatin on blood lipid levels,MMP-9 levels and cardiac function in patients with acute myocardial infarction and its therapeutic effect.Methods A total of 124 patients with acute myocardial infarction treated in our hospital between February 2014 and September 2016 were selected and equally divided into the control group and the observation group according to treatment methods.Patients in the control group received routine treatment,while thosethe observation group was additionally given atorvastatin.The therapeutic effects of the two groups were compared.Results After treatment,the levels of blood lipids(TG,TC,LDL-C)and cardiac function index(LVEDD,IVST)in the two groups were lower,but the levels of HDL-C and LVEF were higher.The blood lipid index and cardiac function level of the observation group were better than those of the control group(P<0.05).After treatment,the levels of CD63,CD62P,ET,MMP-9,CD40L and H-FABP in the two groups were all lower.The levels of CD63,CD62P,ET,MMP-9,CD40L and H-FABP in the observation group were all lower than those of the control group(P<0.05).Conclusion Atorvastatin used for acute myocardial infarction can effectively improve the level of blood lipids,cardiac function and endothelial function,inhibit platelet activation and stabilize plaques.