创伤性骨折患者氧化应激指标变化及中医治疗效果研究

Changes of Oxidative Stress Indexes and Therapeutic Effect of TCM in Patients with Traumatic Fracture

目的探讨创伤性骨折后患者超氧化物岐化酶(SOD)、丙二醛(MDA)、血浆纤维蛋白原定量(Fib)、活化部分凝血酶时间(APTT)水平的变化及复元活血汤的治疗效果。方法回顾性分析100例骨折患者(骨折组)及100例健康志愿者(对照组)的临床资料,比较其SOD、MDA、Fib、APTT的变化。骨折患者中50例给予复元活血汤联合常规治疗(中医治疗组),另外50例患者仅给予常规治疗(常规治疗组),比较两组患者治疗后SOD、MDA、Fib、APTT水平的变化,并对两组患者的骨痂形成时间、软组织修复时间、自觉疼痛完全缓解时间、骨折愈合时间以及治疗后生活质量进行比较。结果骨折组和对照组APTT差异无统计学意义(P>0.05);骨折组SOD水平明显低于对照组,MDA及Fib水平则明显高于对照组,差异均有统计学意义(P<0.05)。中医治疗组和常规治疗组APTT差异无统计学意义(P>0.05);中医治疗组患者SOD水平明显高于常规治疗组,MDA及Fib水平则明显低于常规治疗组,差异均有统计学意义(P>0.05)。中医治疗组骨痂形成时间、软组织修复时间、自觉疼痛缓解时间及骨折愈合时间均明显短于常规治疗组,中医治疗组患者在生理健康水平、心理健康水平及独立能力方面的得分均明显高于常规治疗组,但两组患者的社会支持得分未见显著性差异。结论创伤性骨折可引起机体应激反应,患者SOD水平明显降低,MDA及Fib水平则明显升高。中医治疗有助于改善凝血功能,修复软组织,促进骨痂生成,加快骨折愈合,改善患者生活质量。

Objective To investigate the changes of SOD,MDA,Fib,APTT levels and the therapeutic effect of Fuyuan Huoxue decoction in patients with traumatic fracture.Methods The clinical data of 100 traumatic fracture patients(fracture group)and 100 healthy volunteers(control group)was analyzed retrospectivey.The levels of superoxide dismutase(SOD),malondialdehyde(MDA),plasma fibrinogen(Fib)and activated partialthromboplastin time(APTT)were compared between the two groups.Among these fracture patients,50 cases were treated with Fuyuan Huoxue decoction combined with routine therapy(TCM treatment group),while the other 50 patients were given routine treatment alone(routine treatment group).The changes of SOD,MDA,Fib and APTT after treatment in both groups of patients were compared.The callus formation time,soft tissue repair time,pain relief time,fracture healing time and quality of life after treatment were also compared between the two groups.Results There was no significant difference in APTT between the fracture group and the control group(P>0.05).The level of SOD in the fracture group was significantly lower than that of the control group,while the levels of MDA and Fib were significantly higher than those of the control group,with statistically significant difference(P<0.05).There was no significant difference in APTT between the TCM treatment group and the routine treatment group(P>0.05).The callus formation time,soft tissue repair time,pain relief time,and fracture healing time were significantly shorter in the TCMtreatment group than those in the routine treatment group.The scores of physiological health levels,mental health levels and independent ability of the TCM treatment group were significantly higher than those in the routine treatment group,but there was no significant difference in social support scores between the two groups.Conclusion Traumatic fracture can cause stress response of the body.The level of SOD decreases obviously,while the levels of MDA and Fib increase obviously.TCM treatment can help to improve the function of coagulation,repair the soft tissue,promote the formation of callus,accelerate the healing of the fracture,and improve the quality of life of patients.