复方益母草口服液与缩宫素预防产后出血的效果及对应激反应的影响

Therapeutic Effect of Compound Motherwort Oral Solution and Oxytocin in Prevention of Postpartum Hemorrhage and Its Effect on Stress Response

目的分析复方益母草与缩宫素预防产后出血的效果及对应激反应的影响。方法选取2016年1-12月我院收治的采用产钳助产的产妇67例,根据治疗方法不同分为对照组和观察组。对照组胎儿娩出后注射缩宫素,观察组胎儿娩出后注射缩宫素加复方益母草口服液,比较两组治疗效果和应激反应严重程度。结果两组治疗前后血压水平比较无统计学差异(P>0.05);观察组产后出血发生率和产后2~24 h出血量少于对照组(P<0.05)。治疗前,两组脂质过氧化物(LPO)、C反应蛋白(CRP)、肿瘤坏死因子(TNF-α)水平比较无统计学差异(P>0.05);治疗后,观察组LPO、CRP、TNF-α水平低于对照组(P<0.05)。观察组24 h后子宫复旧情况略优于对照组,但无统计学差异(P>0.05);观察组不良反应率和阴道壁裂伤率(分别为17.65%和20.59%)明显低于对照组(分别为45.45%和48.48%),组间差异均有统计学意义(P<0.05)。结论复方益母草联合缩宫素可减少产妇产后出血量,减轻应激反应,降低阴道壁裂伤率,安全性高。

Objective To explore the therapeutic effect of compound motherwort oral solution and oxytocin in prevention of postpartum hemorrhage and its effect on stress response.Methods A total of 67 parturient women who delivered a baby with forceps in our hospital between January 2016 and December 2016 were selected and divided into the control group and observation group according to treatment methods.After delivery of fetuses,patients in the control group were injected with oxytocin,while those in the observation group were injected with oxytocin and received compound motherwort oral solution.The effect of treatment and severity of stress reactions in the two groups were compared.Results There was no significant difference in blood pressure levels between the two groups before and after treatment(P>0.05).The incidence of postpartum hemorrhage and the amount of postpartum hemorrhage in the observation group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference in the levels of LPO,CRP,and TNF-alpha between the two groups(P>0.05).After treatment,the levels of LPO,CRP and TNF-alpha in the observation group were lower than those in the control group(P<0.05).The recovery of uterus in the observation group was better than that in the control group after 24 hours,but there was no significant difference between the two groups(P>0.05).The adverse reaction rate and vaginal wall laceration rate in the observation group were 17.65%and 20.59%respectively,compared with 45.45%and 48.48%in the control group,respectively,and the adverse reaction rate and vaginal wall laceration rate in the observation group were lower than those in the control group,with statistically significant difference(P<0.05).Conclusion Compound motherwort oral solution combined with oxytocin can reduce postpartum hemorrhage,relieve stress response,decrease the rate of vaginal wall laceration,and ensure safety.