含木糖醇药物安全性评价及药学监护

Evaluation on the Safety of Xylitol-containing Drug and Pharmaceutical Care

木糖醇是一种天然的五碳糖,在全世界范围内广泛应用于食品及医疗领域,其有效性已得到证实,然而关于其安全性关注较少。2017年6月1日国家食品药品监督管理总局发布第68号公告,要求修改含木糖醇注射剂药品说明书,鉴于此笔者检索国内外文献资料,重点关注与木糖醇使用相关的安全性问题,并归纳总结含木糖醇药品临床使用中的药学监护内容,供医师、药师参考。

Xylitol is a natural 5-carbon sugar.It is used in food and medical field worldwide.Its validity has been proved,however,little attention has been paid to its safety profile.On June 1,2017 the China Food and Drug Administration issued announcement No.68 that request modified with xylitol-containing injection drug labels.In view of this the author retrieves the literature which focus on the safety issue related to xylitol-containing drug,a summarized the content of pharmaceutical care in clinical use for reference by doctors and pharmacists.