麻杏石甘汤对支源体肺炎患儿血清炎症因子、免疫球蛋白水平影响及临床治疗效果研究

Analysis of effect of Maxing Shigan decoction on serum inflammatory factors of pneumonia changes in immunoglobulin levels and clinical therapeutic effect

目的:分析麻杏石甘汤对肺炎血清炎症因子影响、免疫球蛋白水平变化及临床治疗效果。方法:本研究对象选取118例支原体肺炎患儿,按照随机数字表法分成对照组和观察组各59例。对照组患儿给予抗感染、退热等常规治疗,观察组患儿在此基础上辅以麻杏石甘汤治疗。连续治疗5d,对比两组治疗效果、血清炎症因子水平、免疫球蛋白水平、不良反应发生率的差异。结果:治疗后观察组愈显率为96.61%,明显高于对照组的84.75%(P<0.05)。治疗后观察组血清CRP、TNF-α、IL-6水平低于对照组,组间有显著的统计学差异(P<0.05)。治疗后观察组IgG、IgM、IgA水平高于对照组(P<0.05)。治疗期间观察组不良反应发生率为5.08%,低于对照组的18.64%(P<0.05)。结论:采用麻杏石甘汤治疗小儿肺炎的疗效确切,有助于减轻机体炎症反应程度、增强免疫功能,同时降低不良反应风险。

Objective:To analyze the effect of Maxing Shigan decoction on serum inflammatory factors,Gansu pneumonia changes in immunoglobulin levels and clinical therapeutic effect.Methods:118 children with mycoplasma pneumonia were selected and divided into control group and observation group according to random number table,59 cases in each group.The control group were given routine treatment of anti infection,such as fever,the patients in the observation group on the basis of combined Maxing Shigan decoction in the treatment.Continuous treatment of 5d,compared two groups of treatment effect,serum inflammatory factors levels,immunoglobulin levels,adverse reaction rate differences.Results:After treatment,the markedly effective rate of the observation group was 96.61%,which was significantly higher than that of the control group 84.75%,and there was a significant difference between the two groups(P<0.05).After treatment,serum CRP,TNF-a,IL-6 level lower than the control group,there was a significant difference between the groups(P<0.05).After treatment,the observation group IgG,IgM,IgA levels higher than the control group,there was a significant difference between the groups(P<0.05).During the treatment,the incidence of adverse reactions in the observation group was 5.08%,significantly lower than 18.64%in the control group,there was a statistically significant difference between the two groups(P<0.05).Conclusion:The curative effect of Maxing shigan decoction in the treatment of infantile pneumonia,help to reduce inflammation,enhance immune function,and reduce the risk of adverse reactions.