坤泰胶囊对子宫肌瘤患者性激素水平变化的影响研究

The effect of Kuntai capsule on hormones in patients with uterine fibroids

目的:研究坤泰胶囊对子宫肌瘤患者性激素水平变化的影响,为子宫肌瘤治疗提供参考。方法:选取诊治的子宫肌瘤患者80例,随机分为对照组与观察组,每组40例,两组患者给予米非司酮口服,观察组在以上治疗基础上加服坤泰胶囊治疗,连续治疗3个月。观察患者治疗前后血雌二醇、孕酮、促黄体生成素、促卵泡生成素水平变化,子宫肌瘤及子宫体积变化,并对治疗疗效评定。结果:两组患者治疗前雌二醇、孕酮、促黄体生成素、促卵泡生成素水平比较差异无统计学意义(P>0.05),两组治疗前后组内比较治疗后较治疗前下降(P<0.05),两组组间比较治疗后观察组低于对照组(P<0.05);两组患者治疗前子宫肌瘤及子宫体积比较差异无统计学意义(P>0.05),两组治疗前后组内比较治疗后较治疗前缩小(P<0.05),两组组间比较治疗后观察组小于对照组(P<0.05);观察组治疗总有效率为95.00%,高于对照组77.50%(P<0.05)。结论:坤泰胶囊用于治疗子宫肌瘤可有助于降低性激素水平、缩小肌瘤体积,疗效满意。

Objective:To explore the effect of Kuntai capsule on hormones in patients with uterine fibroids,provide reference for clinical treatment of uterine fibroids.Methods:We selected 80 cases of patients with uterine fibroids,divided into control group and observation group,two groups of patients were given Mifepristone treated therapy,the observation group treated with Kuntai capsule treated therapy,maintenance therapy 3 months.Estradiol,progesterone,luteinizing hormone and follicle,uterine fibroids volume and uterine volume of two groups before and after treatment were measured,the clinical curative effect of the two groups.Results:Serum Estradiol,progesterone,luteinizing hormone and follicle showed no significant difference of before treatment in patients with two groups(P>0.05),after treatment than lower than that before treatmentin in patients with two groups(P<0.05),the above index level of the observation group lower than that the control group of after treatment(P<0.05).Uterine fibroids volume and uterine volume showed no significant difference of before treatment in patients with two groups(P>0.05),after treatment than lower than that before treatmentin in patients with two groups(P<0.05),the above index level of the observation group lower than that the control group of after treatment(P<0.05).The tocolysis success rate was 95.00%of the observation group higher than that of the control group was 77.50%(P<0.05).Conclusion:Decline of Kuntai capsule on hormones in patients with uterine fibroids,to reduce the volume of uterine fibroids,curative effect affirmation.