沙参麦冬汤加减联合GP化疗治疗晚期非小细胞肺癌疗效研究

Study on clinical effect of Shashen Maidong decoction combind with GP chemotherapy in treatment of advanced non-small cell lung cancer

目的:研究沙参麦冬汤加减结合吉西他滨加顺铂(GP)化疗对晚期非小细胞肺癌的临床疗效。方法:选取非小细胞肺癌晚期患者68例,按照随机对照原则,将患者分成两组。对照组34例患者予以单纯GP化学疗法,治疗组34例患者在对照组患者治疗的基础上加用沙参麦冬汤。结果:治疗2个周期后,治疗组患者的免疫功能改善情况优于对照组(P<0.05),治疗组患者的各项QLQ-C43生存质量评分高于对照组(P<0.05)。治疗组患者的不良反应发生情况低于对照组(P<0.05),治疗组患者的中医证候积分(19.01±0.37)分低于对照组(27.37±0.95)分(P<0.05),治疗组患者的近期临床总疗效率73.5%(25/34)优于对照组58.8%(20/34)(P<0.05)。结论:沙参麦冬汤加减能有效提高患者的生存质量,提高患者的机体免疫功能,降低化疗不良反应的发生率,并能有效改善患者的临床症状及体征。

Objective:To investigate the Shashen Maidong decoction combined with gemcitabine plus cisplatin(GP)clinical curative effect of chemotherapy on advanced non-small cell lung cancer.Methods:Advanced non-small cell lung cancer patients 68 cases in our hospital were randomly divided into 2 groups.34 patients in control group received only GP chemotherapy,the treatment group of 34 cases treated with Shashen Maidong decoction based on the control group.Results:After 2 cycles of treatment,the improvement of immune function in the treatment group was better than that in the control group(P<0.05),and the scores of QLQ-C43 quality of life in the treatment group were higher than those in the control group(P<0.05).The adverse reaction of patients in the treatment group than the control group(P<0.05),TCM syndrome score of patients in the treatment group(19.01±0.37)was lower than that of control group(27.37±0.95)(P<0.05),the recent clinical efficacy of treatment group patients(25/34)than the control group(20/34)(P<0.05).Conclusion:Shashen Maidong decoction can effectively improve the quality of life of patients,improve the immune function of patients,reduce the incidence of adverse reaction of chemotherapy.