摘要
目的:研究沙参麦冬汤加减结合吉西他滨加顺铂(GP)化疗对晚期非小细胞肺癌的临床疗效。方法:选取非小细胞肺癌晚期患者68例,按照随机对照原则,将患者分成两组。对照组34例患者予以单纯GP化学疗法,治疗组34例患者在对照组患者治疗的基础上加用沙参麦冬汤。结果:治疗2个周期后,治疗组患者的免疫功能改善情况优于对照组(P<0.05),治疗组患者的各项QLQ-C43生存质量评分高于对照组(P<0.05)。治疗组患者的不良反应发生情况低于对照组(P<0.05),治疗组患者的中医证候积分(19.01±0.37)分低于对照组(27.37±0.95)分(P<0.05),治疗组患者的近期临床总疗效率73.5%(25/34)优于对照组58.8%(20/34)(P<0.05)。结论:沙参麦冬汤加减能有效提高患者的生存质量,提高患者的机体免疫功能,降低化疗不良反应的发生率,并能有效改善患者的临床症状及体征。
Objective:To investigate the Shashen Maidong decoction combined with gemcitabine plus cisplatin(GP)clinical curative effect of chemotherapy on advanced non-small cell lung cancer.Methods:Advanced non-small cell lung cancer patients 68 cases in our hospital were randomly divided into 2 groups.34 patients in control group received only GP chemotherapy,the treatment group of 34 cases treated with Shashen Maidong decoction based on the control group.Results:After 2 cycles of treatment,the improvement of immune function in the treatment group was better than that in the control group(P<0.05),and the scores of QLQ-C43 quality of life in the treatment group were higher than those in the control group(P<0.05).The adverse reaction of patients in the treatment group than the control group(P<0.05),TCM syndrome score of patients in the treatment group(19.01±0.37)was lower than that of control group(27.37±0.95)(P<0.05),the recent clinical efficacy of treatment group patients(25/34)than the control group(20/34)(P<0.05).Conclusion:Shashen Maidong decoction can effectively improve the quality of life of patients,improve the immune function of patients,reduce the incidence of adverse reaction of chemotherapy.
作者
宋振民
李慧
强亚杰
宋沛
Song Zhenmin;Li Hui;Qiang Yajie(Kaifeng Hospital of Traditional Chinese Medicine in Henan Province(Kaifeng 475000))
出处
《陕西中医》
2018年第4期461-463,共3页
Shaanxi Journal of Traditional Chinese Medicine
关键词
肺肿瘤
非小细胞/中西医结合疗法
沙参麦冬汤/治疗应用
化学疗法
Non small cell lung cancer/integrated
Chinese traditional and western medicine therapy
Shashen Maidong decoction/therapeutic applications
Chemotherapy