参麦开肺散联合西医治疗系统性硬化症肺纤维化疗效及对气道重塑指标的影响

Effect of Shenmai combined with western medicine treatment in patients with systemic sclerosis pulmonary fibrosis and their influence on airway remodeling

目的:探讨参麦开肺散联合西医治疗系统性硬化症肺纤维化疗效及对气道重塑指标的影响。方法:将56例系统性硬化症肺纤维化随机分为两组,对照组接受常规西医治疗,观察组在对照组基础上联合参麦开肺散治疗,治疗结束后,评估两组患者的治疗效果、CT及血清气道重塑指标。结果:治疗前,两组患者的CT及血清气道重塑指标水平差异无统计学意义(P>0.05),治疗12周后,两组的CT气道重塑指标平均管壁厚度(WT_(mean))、气道面积/总横截面积比值(WA%)、气道壁厚度/外径比值(TDR%)水平均有所降低(P均<0.05),且观察组优于对照组。两组血清中气道重塑指标基质金属蛋白酶-9(MMP-9)、转化生长因子β(TGF-β)、透明质酸(HA)、Ⅲ型前胶原(PCⅢ)均降低(P均<0.05),且观察组低于对照组(P均<0.05)。观察组患者的总有效率高于对照组(P<0.05)。结论:参麦开肺散联合西医治疗可有效提升系统性硬化症肺纤维化患者的治疗效果,抑制气道重塑。

Objective:To study the effect of Shenmai combined with western medicine treatment in patients with systemic sclerosis pulmonary fibrosis and their influence on Airway remodeling.Methods:56 cases of systemic sclerosis pulmonary fibrosis were randomly divided into two groups,the control group received conventional Western medicine treatment,the observation group in the control group based on the combination of Shen Maifei lung treatment,after the end of treatment to assess the treatment effect of the two groups of patients、CT and serum airway remodeling.Results:There was no significant difference in the CT and serum airway remodeling indexes between the two groups before treatment(P>0.05).After 12 weeks of treatment,the mean wall thickness(WTmean)The area/total cross-sectional area ratio(WA%),airway wall thickness/diameter ratio(TDR%)were decreased(P<0.05),and the observation group was better than the control group.The levels of matrix metalloproteinase-9(MMP-9),transforming growth factor-β(TGF-β),hyaluronic acid(HA)and procollagen typeⅢ(PCⅢ)were decreased by P<0.05),And the observation group was lower than the control group(P<0.05).The total effective rate of the observation group was higher than that of the control group(P<0.05).Conclusion:Shenmai combined with Western medicine treatment can improve the therapeutic effect in patients with Systemic sclerosis pulmonary fibrosis,inhibit airway remodeling.