黄芪注射液联合胰岛素泵强化治疗糖尿病肾病Ⅲ期疗效研究

Effect of short-term insulin-pump intensive stress combined with astragalus injection on the therapy for early diabetic nephropathy

目的:探讨胰岛素泵强化联合黄芪注射液治疗早期糖尿病肾病(糖尿病肾病Ⅲ期)疗效。方法:选择68例早期糖尿病肾病患者,随机分为对照组和观察组。对照组给予常规胰岛素治疗,观察组给予胰岛素泵强化联合黄芪注射液,治疗周期为2周,分析对比两组患者尿微量白蛋白(mALB),尿微量白蛋白与肌酐比(UACR),尿β2微球蛋白(Uβ2MG),尿N-己酰-B-D-氨基葡萄糖苷酶(NAG),血清胱抑素C(Cys-C),糖化白蛋白(GA),并对比治疗效果。结果:治疗后两组患者的GA、mALB、UACR、Uβ2MG均有所改善,与治疗前相比有统计学意义(P<0.05)。观察组的NAG无明显改善,对照组的NAG及Cys-C无明显改善(P>0.05)。与对照组相比,观察组的GA、mALB、UACR、Cys-C、NAG均明显改善,结果有统计学意义(P<0.05),Uβ2MG改善不明显,无统计学意义(P>0.05)。结论:胰岛素泵强化联合黄芪注射液治疗能够更早的使患者血糖达标,改善血糖波动,保护胰岛细胞功能,减少早期糖尿病肾病的尿微量白蛋白,改善肾功能,有效的抑制早期糖尿病肾病的进展,值得在临床上使用。

Objective:To observe the effects of insulin-pump combined with astragalus injection on early diabetic nephropathy(DN).Methods:68 cases of early DN patients were randomly divided into two groups,32 patients in observed group.36 patients in control group.The patients of control group received routine subcutaneous injections of insulin therapy.The patients of observed group received with short-term insulin pump intensive treatment combined with astragalus injection.Two groups were treated for 2 weeks.Urine microalbumin,urine microalbumin/urine creatinine,β2microglobulin,NAG,cystain C levels,glycated albumin(GA)of the two groups before and after the treatment were compared.Results:After 2 weeks of treatment,GA,mALB,UACR,Uβ2MG were improved in both two groups(P<0.05).GA,mALB,UACR,Cys-C and NAG of observed group were better than control group except Uβ2MG,the differences were statistically significant(P<0.05).Conclusion:The effect of short-term insulin-pump intensive stress combined with astragalus injection in treating early diabetic nephropathy is good.The method can control the development of diabetic nephropathy and it is worthy to promote in clinic.