奥美拉唑联合法莫替丁治疗反流性食管炎的临床疗效及安全性分析

Clinical efficacy and safety analysis of omeprazole combined with famotidine in patients with reflux esophagitis

目的分析奥美拉唑联合法莫替丁治疗反流性食管炎的临床疗效及安全性。方法对我院收治的119例反流性食管炎患者按随机数字表法进行分组,对照组59例患者采用奥美拉唑治疗,观察组60例患者给予奥美拉唑联合法莫替丁治疗,比较两组患者的临床治疗效果、症状体征改善情况及不良反应发生率。结果观察组总有效率为96.67%高于对照组的84.75%,差异有统计学意义(P<0.05);观察组治疗后的反食、烧灼感、反酸症状体征改善幅度优于对照组,不良反应发生率低于对照组,差异均有统计学意义(P<0.05)。结论法莫替丁联合奥美拉唑能有效消除反流性食管炎的症状体征,且安全性高,不良反应低,值得临床应用。

Objective To analyze the effect of omeprazole combined with famotidine in the treatment of reflux esophagitis. Methods Randomly in our hospital 119 cases of patients with reflux esophagitis group,59 cases in the control group were treated with omeprazole,60 cases in observation group were combined with famotidine in the treatment,the clinical efficacy,the two groups were compared after treatment of symptoms and signs of improvement and the incidence of adverse reactions. Results The total efficiency of the observation group was 96.67%higher than that of the control group(P<0.05);84.75%patients in the observation group,heartburn,acid reflux regurgitation symptoms improved better than those of the control group(P<0.05);the observation group the incidence of adverse reactions was 5%lower than that of the control group 16.95%(P<0.05). Conclusion Famotidine combined with omeprazole can effectively remove the symptoms and signs of reflux esophagitis patients,and the safety is high.