紫杉醇联合顺铂及氟尿嘧啶治疗胃癌的应用及可行性分析

The clinical application and feasibility of paclitaxel combined with cisplatin and fluorouracil in the treatment of gastric cancer

目的探讨紫杉醇联合顺铂及氟尿嘧啶治疗胃癌的效果及可行性。方法将50例胃癌患者随机分为对照组和观察组各25例,对照组的治疗方案为顺铂联合氟尿嘧啶,观察组为顺铂、氟尿嘧啶联合紫杉醇,观察比较两组患者的治疗效果、不良反应发生率。结果观察组的近期疗效为56.00%,显著高于对照组的36.00%,差异有统计学意义(χ2=3.945,P=0.047);两组患者的白细胞减少、脱发、恶心等不良反应发生率比较,差异无显著统计学意义(P>0.05)。结论紫杉醇联合顺铂及氟尿嘧啶治疗中晚期胃癌能获得较为理想的近期疗效,且不良反应少,安全性较高,值得推广应用。

Objective To study and analyze the efficacy and feasibility of paclitaxel combined with cisplatin and fluorouracil in the treatment of gastric cancer. Methods A total of 50 cases of patients with gastric cancer were collected and randomly divided into control group(25 cases)and observation group(25 cases). Results The immediate effect of the observation group was 56.00%,significantly higher than 36.00%in the control group(χ2=3.945,P=0.047);there was no significant difference between the two groups of leukocyte reduction,hair loss,nausea and other adverse reactions(P>0.05). Conclusion In the treatment of gastric cancer patients,paclitaxel combined with cisplatin and fluorouracil can achieve relatively satisfactory short-term effect,with less adverse reactions and high safety,so it is worthy of popularization and application.