血清GDF-15 mRNA与大肠癌患者病理特征的关系

Relationship between serum GDF-15 mRNA and pathological features in patients with colorectal cancer

目的探讨血清生长分化因子-15(GDF-15)的mRNA水平与大肠癌患者病理特征的关系。方法选择70例于我院采取手术治疗的大肠癌患者为研究对象,并收集大肠癌患者癌组织切除标本,所有癌组织标本均经病理确诊。分析大肠癌患者各病理特征与GDF-15表达率的关系。结果 GDF-15在大肠癌患者中的阳性表达率为72.86%。GDF-15的阳性表达率与大肠癌患者性别、年龄、肿瘤发生部位、组织学类型、肉眼分型比较,无显著差异(P>0.05)。低分化、有淋巴结转移及C、D期大肠癌患者GDF-15的阳性表达率分别高于高、中分化、无淋巴结转移及A、B期大肠癌患者,差异有统计学意义(P<0.05)。结论血清GDF-15 mRNA水平可反映肿瘤恶性程度、分化程度及是否存在淋巴结转移,在大肠癌的发生、发展中起重要作用,对临床诊断及治疗具有一定的指导意义。

Objective To investigate the relationship between serum GDF-15 mRNA and pathological features in patients with colorectal cancer.Methods Seventy cases of patients with colorectal cancer who underwent surgical treatment in our hospital were enrolled in this study.Colorectal cancer tissue specimens of patients were collected and confirmed by pathology.The relationship between the serum GDF-15 expression and pathological features were analyzed.Results The positive expression rate of serum GDF-15 in patients with colorectal cancer was 72.86%.The positive expression rate of serum GDF-15 was not associated with sex,age,tumor location,histological type and macroscopic classification(P>0.05).The positive expression rates of GDF-15 in patients with low differentiation,lymph node metastasis and C,D stage in colorectal cancer were higher than those of high or middle differentiation,without ymph node metastasis and A,B stage in colorectal cancer(P<0.05).Conclusion The level of serum GDF-15 mRNA can reflect the degree of malignancy,differentiation and lymph node metastasis,which may play an important role in the occurrence and development of colorectal cancer.It has certain guiding significance for clinical diagnosis and treatment