乌司他丁对老年重度脓毒症患者肠屏障功能及预后的影响

Effects of ulinastatin on intestinal barrier function and prognosis in elderly patients with severe sepsis

目的研究乌司他丁对老年重度脓毒症患者肠屏障功能及预后的影响。方法将我院收治的60例老年重度脓毒症患者作为研究对象,随机分为对照组和观察组,各30例。对照组给予常规治疗,观察组在常规治疗基础上加用乌司他丁。比较两组患者的临床效果。结果治疗第2天及治疗1周时两组患者的血浆IFABP、DAO、D-Lac、血清PCT水平及治疗1周时APACHEⅡ评分均明显优于治疗前,且观察组明显优于对照组(P<0.05)。两组患者28 d内死亡率比较,差异无统计学意义(P>0.05)。结论乌司他丁能显著改善老年重度脓毒症患者肠道屏障功能,但其对预后生存率改善作用有限。

Objective To study the effects of ulinastatin on intestinal barrier function and prognosis in elderly patients with severe sepsis.Methods Sixty elderly patients with severe sepsis were selected and randomly divided into control group and observation group,with 30 cases in each group.The control group was given routine treatment,and the observation group was treated with ulinastatin on the basis of routine treatment.The clinical effects of the two groups were compared.Results The levels of IFABP,DAO,D-Lac,PCT at 2nd day of the treatment and 1 week after treatment and APACHEⅡscores at 1 week after treatment of the two groups were better than those before treatment,and those of the observation group were better than the control group(P<0.05).There was no significant difference in the mortality rate between the two groups in 28 days(P>0.05).Conclusion Ulinastatin can significantly improve intestinal barrier function in elderly patients with severe sepsis,but the effect on the improvement of survival rate is limited.