文拉法辛治疗伴有抑郁或焦虑的功能性胃肠道疾病时出现的不良反应

Adverse reactions induced by venlafaxine in treatment of functional gastrointestinal disease associated with depression or anxiety

目的 :观察文拉法辛的不良反应的发生率和表现。方法 :78例 (住院病人 4 8例 ,门诊病人 30例 )伴有明显抑郁或焦虑的功能性胃肠道疾病的病人服用文拉法辛 ,开始剂量 2 5～ 5 0mg·d- 1,以后渐增至 10 0mg·d- 1,定期观察出现的不良反应。结果 :总不良反应发生率为 19% (15 /78) ,胃肠道反应率为 13% (10 /78) ,其次为头痛、失眠和 5 羟色胺 (5 HT)综合征、口干与高血压病人的血压控制不良 ,另可致眼压增高 (慢性青光眼发作 )及可致肥胖。出现不良反应的 15例病人中不能耐受而需要停药者有 3例 ,均为女性。结论 :文拉法辛的不良反应除文献报道外 ,尚可致眼压增高 ,长期应用可能致肥胖。

AIM: To observe the occurrence rate and manifestations of the adverse reactions of venlafaxine. METHODS: Seventy-eight patients (in-patients forty-eight, out-patients thirty) with functional gastrointestinal disease associated with obvious depression or anxiety received venlafaxine 25-50 mg·d -1, po, initially; then increased gradually to 100 mg·d -1, and were observed the adverse reactions at regular intervals. RESULTS: The total adverse reactions rate was 19 %(15/78). The adverse reactions of gastrointestinal tract were 13 %(10/78), and next were headache, insomnia, 5-HT syndrome, xerostomia and bad-control of the hypertension. The new adverse reactions were an increase of intra-ocular tension (attack of the chronical glaucoma), and body weight gain. Three women patients of fifteen wanted to stop taking it because they could not tolerate. CONCLUSION: The adverse reactions of venlafaxine are an increase of intra-ocular tension and body weight gain after long-term treatment besides those reported by the literatures. When the patients with glaucoma or hypertension can not tolerate, it should be forbade or used carefully.