普米克令舒联用可必特雾化吸入对喘息型肺炎患儿血清IL-4、IL-6和IL-8的影响

Effect of pulmicort combined combivent inhalation on serum IL-4 and IL-6 and IL-8 in asthmatic pneumonia

目的:探讨普米克令舒联用可必特雾化吸入对喘息型肺炎患儿血清IL-4、IL-6和IL-8的影响。方法:随机选取2015年5月至2016年7月在我院就诊的76例喘息型肺炎患儿作为研究对象,按治疗方法将其分为对照组和观察组,每组各38例。对照组患儿采取平喘、持续低流量吸氧、抗生素控制感染以及可必特2.5ml tid等基础治疗,观察组患儿在对照组治疗的基础上加用普米克令舒0.25mg bid雾化吸入治疗。观察比较两组患儿治疗7d后的临床疗效、临床症状及体征消失时间、治疗前、治疗后IL-4、IL-6和IL-8等炎性因子水平变化等具体情况。结果:(1)观察组总有效率明显优于对照组(97.36%vs 84.21%,P<0.05);(2)观察组患儿气喘、咳嗽、肺部音、喘鸣音消失时间均显著低于对照组(P<0.05);(3)治疗后,两组患儿IL-4、IL-6和IL-8水平均较治疗前明显降低,且观察组各项炎症因子均明显低于对照组(P<0.05)。结论:喘息型肺炎患儿应用普米克令舒联合可必特雾化吸入治疗具有良好的临床疗效,能有效缓解患儿临床症状及体征,控制炎性因子水平,值得临床推广应用。

Objective:To investigate the effect of pulmicort combined combivent inhalation on serum IL-4 and IL-6 and IL-8 in asthmatic pneumonia.Methods:Seventy-six asthmatic children with pneumonia in our hospital from May 2015 to July 2016 were randomly selected as the subjects,according to the treatment methods,all patients were divided into control group and observation group,38 cases in each group.The patients in control group were treated with continuous low flow oxygen,antibiotics to control infection and combivent therapy 2.5ml tid and other basic treatment,the patients in observation group were treated with pulmicort 0.25 mg bid inhalation treatment.Observe and comparethe clinical efficacy,clinical symptoms and signs disappearance time,the changes of inflammatory factors such as IL-4,IL-6 and IL-8 before and after treatment between the two groups after 7 d treatment.Results:(1)The total effective rate of the observation group(97.36%)was obviously better than that of the control group(84.21%)(P<0.05);(2)The time of asthma,cough,pulmonary rate and wheezing in observation group were significantly lower than that in control group(P<0.05);(3)After treatment,the levels of IL-4,IL-6 and IL-8 in the two groups were significantly lower than those before treatment,and the inflammatory factors in the observation group were significantly lower than those in the control group(P<0.05).Conclusion:Pulmicort combined with combivent inhalation therapy has a good clinical effect on asthmatic pneumonia,it can effectively alleviate the clinical symptoms and signs of children,and control the level of inflammatory factors,so it is worthy of clinical application.