纳洛酮联合氨茶碱对新生儿呼吸暂停的疗效分析

Curative effect analysis of naloxone combined with aminophylline on neonatal apnea

目的观察纳洛酮联合氨茶碱对新生儿呼吸暂停的疗效。方法选取2015年1月至2016年12月我院出生并确诊为新生儿呼吸暂停综合症的68例患儿为研究对象,随机分为观察组和对照组,各34例。对照组患儿给予纳洛酮治疗,观察组在对照组基础上给予氨茶碱治疗,一个疗程后比较两组患儿呼吸暂停发生次数、持续时间、血氧饱和度、心率和治疗效果。结果观察组患儿呼吸暂停次数、持续时间都优于对照组,差异有统计学意义(P<0.05);观察组患儿血氧饱和度、心率均高于对照组,差异有统计学意义(P<0.05);治疗后观察组患儿总有效率为88.2%,高于对照组的76.5%,差异有统计学意义(P<0.05)。结论纳洛酮联合氨茶碱对新生儿呼吸暂停的治疗具有显著疗效。

Objective To observe the curative effect of naloxone combined with aminophylline on neonatal apnea.Methods From January 2014 to December 2016,68 cases of neonatal apnea in our hospital were randomly divided into observation group and control group,with 34 cases in each group.The control group was given naloxone treatment,the observation group was given aminophylline treatment on the basis of the control group.After a course of treatment,the times of apnea,duration time,blood oxygen saturation,heart rate and therapeutic effects were compared between the two groups.Results The apnea times and duration time in the observation group were obviously better than those in the control group,and the differences were statistically significant(P<0.05).The blood oxygen saturation and heart rate in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The total effective rate of the observation group was 88.2%,which was higher than 76.5%of the control group,and the differences were statistically significant(P<0.05).Conclusion Naloxone combined with aminophylline has a significant effect on the treatment of neonatal apnea.