摘要
药源性葡萄膜炎是一种较少见的疾病。尽管如此,九十年代在艾滋病患者中使用预防结核药物利福布丁而引发葡萄膜炎,加深了对药物在葡萄膜炎炎症发生中潜在作用的认识。以Naronjo建立的药源性疾病的诊断标准衡量,可以获知至少120种药物与葡萄膜炎发生相关,本文重点介绍其中最为常见的7类药物,包括抗骨质疏松类(二碳磷酸盐类),抗病毒类(西多福韦),抗结核药(利福布丁),抗青光眼药,眼内注射药,抗TNFα药物以及疫苗。了解这些常见的药源性葡萄膜炎药物,有利于临床识别这种特殊类型的葡萄膜炎。
Drugs induced uveitis is a rare disease.Nevertheless,uveitis induced by rifabutin which used as preventing tuberculosis drug in AIDS patients in 1990s,to some extent,enhance the knowledge of the potential effect of some drugs causing uveitis.According to the diagnostic criteria of drug-induced diseases developed by Naronjo,more than 120 drugs had been found to be related with uveitis.This review mainly introduces 7 common drugs,including anti-osteoporosis drugs(bisphosphonates),anti-virus drugs(cidofovir),anti-tuberculosis drugs(rifabutin),anti-glaucoma drugs,intravitreal drugs,anti-TNFαantibody,and vaccines.Therefore,knowing the common known drugs can help better understand and distinguish the disease.
作者
杨永升
YANG Yongsheng(Department of Ophthalmology,Eye Hospital of China Academy of Chinese Medical Sciences,Beijing 100040,China)
