可溶性VEGF受体1在视网膜新生血管疾病中的研究进展

Research on soluble VEGF receptor 1 in retinal neovascularization

视网膜新生血管性疾病的共同特征是病理性新生血管形成。目前研究的内源性视网膜新生血管因子最主要的是VEGF。可溶性VEGF受体1(sFlt-1)是VEGFR-1的mRNA胞外区剪接形成的可溶性形式,只编码胞外区,缺乏细胞内酪氨酸激酶区域,所以其仅具有与配体结合的能力,而无信号转导能力,从而阻止新生血管的形成。s Flt-1作为近年来的研究热点,有可能成为治疗该类疾病的新的基因治疗方法。本文就s Flt-1在视网膜新生血管疾病治疗中的作用机制及研究进展做一综述。

The common feature of retinal neovascularization is the formation of pathological neovascularization.The primary one of endogenous retinal neovascularization factor in current research is vascular endothelial growth factor(VEGF).SFlt-1,the soluble form of splicing in mRNA extracellular region of VEGFR-1,which is short of intracellular tyrosine kinase domain can only encode the extracellular domain.Therefore,it only can bind with ligands but can not transmit signals,thus preventing the formation of neovascularization.SFlt-1,as a hot research topic in recent years,may provide a new gene therapy method for this disease.This review focus on the mechanism and research progress of sFlt-1 in retinal neovascularization.