RhD变异型患者产生类同种抗-D抗体一例分析

Analysis of Analogous Autoanti-D Autoantibody in One RhD Variant Patient

目的探讨RhD变异型患者产生类同种抗-D抗体的血清学特点及原因。方法对我院收治的RhD变异型1例的临床资料进行回顾性分析。结果本例因肝硬化失代偿8年,病情加重3 d再次入院。患者血型为A型RhD阳性,由于病情反复发作及贫血等原因多次输血,复检血型为Rh阳性D变异型,同时血清中产生类同种抗-D抗体。后选择A型RhD阴性ccdee的血液与患者血清进行交叉配血,结果主侧配血相符,输注红细胞2 U,未出现不良反应。结论 RhD变异型患者产生类同种抗-D抗体临床少见,选择避开类同种抗体的洗涤红细胞输注可保障输血安全。

Objective To analyze the serological characteristic and causes of analogous isoanti-D autoantibody in one patient with RhD variant.Methods Clinical data of one patient with RhD variant was retrospectively analyzed in our hospital.Results The patient with a history of decompensated liver cirrhosis for more than 8 years was rehospitalized because of hemafecia,nausea and aggravation of the condition for 3 d.Repeated attacks and anemia led to blood transfusion,in which RhD positive blood type was altered to RhD positive variant accompanied with the analogous isoanti-D autoantibody in serum.RhD negative blood ccdee was selected for cross matching,followed by 2U RBC transfusion without adverse reactions.Conclusion It was extremely rare for patients with RhD variant to produce analogous isoanti-D autoantibody in serum.We consider it safe to choose the washed RBC without analogous autoantibody for transfusion.