慢性萎缩性胃炎患者血清胃蛋白酶原、胃泌素17水平与年龄的相关性分析

Correlation of Serum Pepsinogens and Gastrin 17 With Age in Patients with Chronic Atrophic Gastritis

背景:慢性萎缩性胃炎(CAG)为消化系统的常见疾病,是肠型胃癌的癌前病变。血清胃蛋白酶原(PGs)、胃泌素17(G17)是胃黏膜病变的生物学标记物,在CAG诊断和早期胃癌筛查中作用突出。目的:探讨CAG患者血清PGs、G17水平与年龄的相关性。方法:选取2016年1月—2017年9月保定市第一中心医院收治的CAG患者582例,利用ELISA法检测血清PGⅠ、PGⅡ和G17水平,计算PGⅠ/PGⅡ比值(PGR),分析上述指标与患者临床参数的相关性。结果:CAG患者血清PGⅠ、PGⅡ水平随年龄增长而升高(P<0.01),PGR、G17水平随年龄增长而降低(P<0.05)。Spearman秩相关系数分析显示,PGⅠ、PGⅡ水平与年龄呈正相关(r_s=0.374,P<0.01;r_s=0.559,P<0.01),PGR、G17水平与年龄呈负相关(r_s=-0.649,P<0.01;r_s=-0.141,P<0.05)。结论:CAG患者血清PGⅠ、PGⅡ和G17水平与年龄之间存在相关性。血清PGs和G17作为CAG诊断和早期胃癌筛查的血清学指标时,应考虑年龄因素的影响。

Background:Chronic atrophic gastritis(CAG)is a common disease of digestive system and is a precancerous lesion of the intestinal type gastric cancer.Serum pepsinogens(PGs)and gastrin 17(G17)are biological markers of gastric mucosal lesions,which have a prominent role in diagnosis of CAG and screening of early gastric cancer.Aims:To study the correlation of serum PGs and G17 with age in patients with CAG.Methods:A total of 582 CAG patients admitted from Jan.2016 to Sep.2017 at the Baoding First Central Hospital were enrolled.The levels of serum PGⅠ,PGⅡand G17 were determined by ELISA,and the PGⅠ/PGⅡratio(PGR)was calculated.The correlations of these indices with the clinical data of CAG patients were analyzed.Results:The levels of serum PGⅠand PGⅡwere increased with age(P<0.01),and the levels of PGR and G17 were decreased with age(P<0.05).Spearman rank correlation coefficient analysis showed that the levels of PGⅠand PGⅡwere positively correlated with age(r s=0.374,P<0.01;r s=0.559,P<0.01),and the levels of PGR and G17 were negatively correlated with age(r s=-0.649,P<0.01;r s=-0.141,P<0.05).Conclusions:The levels of serum PGⅠ,PGⅡand G17 in patients with CAG were correlated with age.When serum PGs and G17 are used as serological indicators for diagnosis of CAG and screening of early gastric cancer,the impact of age on these indices should be taken into account.