药品不良反应183例报告分析

Analysis of 183 cases of adverse drug reactions

目的分析我院药品不良反应(ADR)发生的特点及相关影响因素,为提升临床合理用药与ADR监测水平提供参考。方法采用回顾性研究方法,对我院2014年—2016年上报的183例ADR报告,按患者年龄与性别、药品种类、给药途径、临床表现、ADR级别和结果等进行整理分析。结果 183例药品不良反应报告中,以60岁以上老年患者居多,占78.68%;静脉给药是引起药品不良反应的主要给药途径,占77.04%;临床表现以胃肠道系统损害为主,占34.63%;中成药与抗菌药物引起的药品不良反应居前两位,分别占22.40%与20.76%。结论中药注射剂是ADR监测重点药物类别,老年患者是ADR监测重点人群,静脉给药是ADR监测重点给药途径。

Objective To raise the reasonable use of drugs clinically and the monitoring level of adverse drug reaction(ADR),we analyzed retrospectively the characteristics and risk factors of 183 Cases of adverse drug reactions in our hospital.Methods One hundred and eighty-threeADRs from our hospital during 2014-2016 were analyzed according to patients’age and gender,drug types,administration route,clinical features,the severe level of ADR.Results Among the 183 ADR reports,higher incidences of ADRs(78.68%)appeared in elderly patients(≥60 years);ADR cases caused by intravenous administration were most common(77.04%);ADRs were mainly caused by Traditional Chinese Medicine(22.40%)and antibacterial agents(20.76%).The major clinical features was gastrointestinal disorders(34.63%);at most.Conclusion Medical staffs should monitor seriously the Traditional Chinese Medicine via intravenous administration,and the elderly patients.