血管紧张素Ⅱ对乳腺癌细胞迁移的影响

Angiotensin Ⅱ Promotes the Migration of Breast Cancer Cells

乳腺癌是女性发病率高且恶性程度高的肿瘤,肿瘤侵袭转移是导致患者死亡的重要原因,研究与癌细胞转移相关的因子或指标具有重要意义.本实验采用血管紧张素Ⅱ(AngⅡ)处理乳腺癌细胞MDA-MB-231,可促进肿瘤细胞迁移,增强到1.51倍.Q-PCR检测结果表明,AngⅡ能够明显刺激MDA-MB-231细胞中u PA(2.97倍)和u PAR的表达.因此,AngⅡ刺激乳腺癌细胞u PA和u PAR的表达,可能是AngⅡ促进乳腺癌细胞迁移的原因之一.

Breast cancer is a high incidence and malignant tumor in women.The invasion and metastasis are the major reasons that leading to the death of patients.It is of great significance to study the factors and biomarkers associated with cancer metastasis.In this study,the migration of breast cancer cells MDA-MB-231 treated with the angiotensinⅡ(AngⅡ)was enhanced.The AngⅡsignificantly stimulated the expression of uPA(2.97 times)and uPAR in MDA-MB-231 cells by the Q-PCR measurement.Therefore,the AngⅡcould stimulate the expression of uPA and uPAR in breast cancer cells,which maybe one of the reasons promoting breast cancer cell migration by AngⅡ.