液体绷带皮肤刺激性和过敏性实验研究

Experimental study on skin irritation and anaphylaxis of liquid bandage

目的:观察液体绷带外用对皮肤的刺激性和过敏性反应,为评价其安全性提供实验依据。方法:皮肤刺激实验:将新西兰兔分为完整皮肤组和破损皮肤组,分别单次给药1 d、连续给药7 d后观察皮肤有无红斑、水肿等异常反应。皮肤过敏实验:分别在第0天、第7天和第14天对豚鼠给予受试物致敏1次,于末次致敏后的第14天对皮肤再次给药进行攻击激发,观察皮肤有无红斑、水肿等过敏反应情况。结果:液体绷带对新西兰兔完整皮肤和破损皮肤单次给药或多次给药均未见红斑及水肿反应,刺激反应平均分值均<0.5分,无刺激性;液体绷带致敏豚鼠皮肤未出现明显红斑、水肿等过敏反应或其他全身过敏反应。结论:液体绷带对新西兰兔完整皮肤和破损皮肤不会引起刺激性反应,对豚鼠皮肤无过敏性反应,具备良好的皮肤用药安全性。

Objective To observe the skin irritation and anaphylaxis of the liquid bandage to facilitate its safety evaluation.Methods In case of skin irritation test,some New Zealand rabbits were divided into an unaffected skin group and an affected skin group,and had their skin observed for erythema,edema and etc after undergoing 1-d and 7-d administration respectively;in case of anaphylaxis,the guinea pigs went through drug sensitization respectively at the 1st,7th and 14th days and experienced re-sensitization 14 days after,and the symptoms of anaphylaxis were observed such as erythema and edema.Results The liquid bandage had no irritation to the unaffected and affected skin of New Zealand rabbit by single or multiple administration with the irritation mean value being lower than 0.5.There were no anaphylaxis symptoms such as erthema and edema found in the guinea pig by the liquid bandage.Conclusion The liquid bandage proves its skin safety by non-irritation to the unaffected and affected skin of New Zealand rabbit and non-anaphylaxis to the guinea pig