丹参川芎嗪注射液对重度烧伤患者炎性因子影响及预防脓毒症发生效果分析

Effect of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection on the Inflammatory Factors of Severe Burn Patients and the Prevention of Sepsis

目的:探讨丹参川芎嗪注射液对重度烧伤患者炎性因子影响及预防脓毒症发生效果。方法:收集2013年4月至2017年3月入院的80例重度烧伤患者随机分为两组,对照组患者给予常规治疗,观察组患者则加用丹参川芎嗪注射液,比较两组患者炎性因子、其他疾病相关参数与脓毒症预防效果。结果:观察组患者治疗后1d、3d、7d、10d与14d的TNF-α、IL-1、IL-6、CRP与PCT水平组间比较均显著性低于对照组;治疗后PT、TT、ALT与AST水平组间比较均显著性低于对照组,差异有统计学意义(P<0.05);SIRS总发生率明显低于对照组,存在明显差异(P<0.05)。结论:丹参川芎嗪注射液对重度烧伤患者炎性因子影响及预防脓毒症发生效果显著,具有借鉴意义。

Objective:To investigate the effect of ligustrazine injection on inflammatory cytokines in severe burn patients and the prevention of sepsis.Methods:80 patients with severe burn admitted to our hospital from April 2013 to March 2017 were randomly divided into two groups.Patients in the control group were given routine treatment.Patients in the observation group were treated with ligustrazine injection.The two groups of patients with inflammatory factors,other diseases related parameters and sepsis prevention effect were compared.Results:The levels of TNF-α,IL-1,IL-6,CRP and PCT in the observation group were significantly lower than those in the control group on the 1st,3rd,7th,10th and 14th day after treatment.ALT and AST levels were significantly lower than the control group,there was a significant difference(P<0.05);SIRS incidence was significantly lower than the control group,there was a significant difference(P<0.05).Conclusion:The effect of Salviae Miltiorrhizae injection on inflammatory factors and prevention of sepsis in patients with severe burn has significant reference value.