Hsp90在胰腺癌组织中表达升高及其临床病理意义

Increased expression of Hsp90 in pancreatic cancer and its clinical pathological significance

目的分析热休克蛋白90(Hsp90)在胰腺癌组织中的表达水平与肿瘤发生、发展和转移的关系及其对预后的影响。方法用市售组织芯片,通过免疫组化法测定2009年1月至2013年8月期间病理确诊为胰腺癌的63例患者癌标本和癌旁组织中的Hsp90表达,用ANOVA或者t检验分析Hsp90表达水平与患者相关临床病理指标之间的关系。结果胰腺癌组织中Hsp90的表达量显著高于癌旁组织,与肿瘤的病理分级、淋巴结转移、临床分期、TNM分期有关(P<0.05)。结论胰腺癌组织中高表达Hsp90与胰腺癌的高侵袭、高转移能力密切相关,高表达的Hsp90可能作为胰腺癌的预后指标以提示患者预后差。

Objective To explore the expression and meaning of heat shock protein 90(Hsp90)in pancreatic cancer and its correlation with the occurrence,development and metastasis of the tumor tissues and its influence on prognosis.Methods Via immunohistochemical staining,this study used the commercial tissue chip to determine the expression of Hsp90 in 63 pancreatic cancer resection specimens and their para-cancerous counterparts,which were pathologically confirmed from January 2009 to August 2013.We also analyzed the correlation with patient s clinical parameters by using one-way ANOVA or t test.Results Hsp90 expression in pancreatic cancer tissues was significantly higher than tissue adjacent to carcinoma,and it was associated with histological grade,lymph node metastasis,clinical and TNM phase of pancreatic cancer(P<0.05).Conclusions Hsp90 is highly expressed in pancreatic cancer tissues,and its expression is associated with invasion and metastasis of pancreatic cancer.Therefore,Hsp90 may serves as a prognostic indicator of pancreatic cancer while its high expression may represent poor prognosis of pancreatic cancer patients.