摘要
结肠炎相关结肠癌(CAC)的发生和发展与溃疡性结肠炎(UC)密切相关。CAC发生、发展和恶性变相关的主要发病机制包括核转录因子(NF-κB)通路、信号传导子和转录激活子(STAT)与相关蛋白通路、肠道菌群失衡、免疫微环境和Toll样受体(TLRs)相关通路等方面内容。
The ulcerative colitis is closely related to colitis associated cancer.The main mechanisms related to the occurrence,development and malignant transformation of CAC includes NF-κB pathway,signal transducers and activator of transcription(STAT)and related protein pathways,intestinal microflora imbalance,the immune microenvironment,Toll-like receptor(TLR)-related pathway and so on.
作者
宋华琛
唐晓楠
张海婧
王文杰
吴练秋
SONG Huachen;TANG Xiaonan;ZHANG Haijing;WANG Wenjie;WU Lianqiu(State Key Laboratory of Bioactive Substances and Functions of Natural Medicines,Institute of Materia Medica, CAMS&PUMC,Beijing 100050,China)
出处
《基础医学与临床》
CSCD
2018年第4期568-572,共5页
Basic and Clinical Medicine
基金
北京市自然科学基金(7172139)
中国医学科学院医学与健康科技创新工程项目(2016-12M-3-011)
关键词
溃疡性结肠炎
结肠炎相关结肠癌
发病机制
ulcerative colitis
colitis-associated colon cancer
pathogenesis mechanism
