阿替普酶溶栓治疗脑梗死临床效果观察

Clinical effect of thrombolytic therapy with alteplase on cerebral infarction

目的:探讨阿替普酶溶栓治疗脑梗死的临床效果。方法:收治脑梗死患者60例,随机分成对照组和观察组。对照组采用血栓通注射液联合拜阿司匹林治疗,观察组在对照组基础上加用阿替普酶,比较两组治疗效果。结果:治疗6 h、治疗24 h、治疗7 d观察组NIHSS评分降低幅度明显大于对照组(P<0.05);两组治疗后血沉、红细胞压积比较,差异无统计学意义(P>0.05);两组血液流变主要指标比较,差异有统计学意义(P<0.05)。结论:阿替普酶溶栓治疗脑梗死疗效显著。

Objective:To explore the clinical effect of thrombolytic therapy with alteplase on cerebral infarction.Methods:60 patients with cerebral infarction were selected,and they were randomly divided into the control group and the observation group.The control group was treated with Xue Shuan Tong injection combined with aspirin,and the observation group added with alteplase on the basis of the control group.We compared the therapeutic effect of two groups.Results:The decrease of NIHSS score in the observation group was significantly greater than that of the control group at 6 hours of treatment,24 hours of treatment and 7 days of treatment(P<0.05).There was no significant difference in erythrocyte sedimentation rate and hematocrit between groups after treatment(P>0.05),and the main indexes of blood rheology were statistically significant(P<0.05).Conclusion:The clinical effect of thrombolytic therapy with alteplase on cerebral infarction was significant.