血液灌流联合血液透析应用于重症有机磷农药中毒的临床效果分析

Analysis of the clinical effect of hemoperfusion combined with hemodialysis in the treatment of severe organophosphorus pesticide poisoning

目的:探讨血液灌流联合血液透析应用于重症有机磷农药中毒的临床疗效。方法:收治重症有机磷农药中毒患者60例,分两组。对照组给予常规急救处理,观察组在此基础上联合血液灌流、血液透析治疗,比较两组阿托品用量、胆碱酯酶活性恢复时间、昏迷至清醒时间及住院时间,同时比较两组转归及相关并发症发生情况。结果:与对照组比较,观察组阿托品用量减少,胆碱酯酶活性恢复时间、昏迷至清醒时间、住院时间均缩短,治愈率提高,死亡率降低,且并发症发生率降低(P<0.05)。结论:对重症有机磷农药中毒患者在常规急救处理基础上联合血液灌流、血液透析治疗,能改善患者预后。

Objective:To investigate the clinical effect of hemoperfusion combined with hemodialysis in the treatment of severe organophosphorus pesticide poisoning.Methods:60 cases of severe organophosphorus pesticide poisoning were selected.They were divided into the two groups.The control group was given routine emergency treatment,and the observation group was combined with hemoperfusion and hemodialysis on this basis.The dosage of atropine,recovery time of cholinesterase activity,coma to wakefulness time and hospital stay were compared between groups.Meanwhile,the outcomes and complications of the two groups were compared.Results:Compared with the control group,the dosage of atropine in the observation group was reduced,the recovery time of cholinesterase activity,the time from coma to wakefulness and hospitalization time were shortened,the cure rate was increased,the mortality rate was reduced,and the incidence of complications decreased(P<0.05).Conclusion:Combined hemoperfusion and hemodialysis can improve the prognosis of patients with severe organophosphorus pesticide poisoning on the basis of routine emergency treatment.