脓毒症患者外周血PCT、CRP、BNP水平与cTnI的关系

The relationship between PCT,CRP and BNP levels in peripheral blood of patients with sepsis and cTnI and its clinical significance

目的探究脓毒症患者外周血清降钙素原(PCT)、C反应蛋白(CRP)、B型脑钠肽(BNP)与肌钙蛋白I(cTnI)的关系及临床意义。方法搜集112例该院2015年4月至2016年4月收治的脓毒症患者,根据患者的病情程度将其分为脓毒症、严重脓毒症及脓毒症休克3组,检测3组患者外周血清PCT、CRP、BNP及心肌损伤指标cTnI水平,分析脓毒症患者血清PCT、CRP、BNP与cTnI的相关性。结果 3组患者PCT、CRP、BNP及cTnI水平比较,脓毒症休克组均显著高于严重脓毒症组,且差异具有统计学意义(P<0.01),严重脓毒症组均明显高于脓毒症组(P<0.01)。相关性分析结果显示,3组脓毒症患者血清PCT、BNP及CRP与cTnI水平均呈正相关(P<0.05),但相关性依次为PCT(r=0.831)>BNP(r=0.456)>CRP(r=0.287)。结论脓毒症患者cTnI与血清PCT、CRP、BNP水平具有不同程度的正相关关系,随着脓毒症患者病情的加重,也会存在更加显著的心肌损伤症状。

Objective To investigate the relationship between serum PCT,CRP,BNP and cardiac troponin I(cTnI)and its clinical significance in patients with sepsis.Methods 112 patients with sepsis treated in our hospital were collected.Patients were divided into sepsis,severe sepsis and septic shock groups according to their degree of illness.The serum levels of cTnI and cTnI were measured in peripheral blood samples of patients with sepsis,severe sepsis and sepsis shock.To analyze the correlation between serum cTnI and cTn I in patients with sepsis.The levels of BNP and cTnI were significantly higher in septic shock group than in severe sepsis group.The difference was statistically significant(P<0.01),and that in severe sepsis group was significantly higher than that in sepsis group(P<0.01).The results of correlation analysis showed that there was a positive correlation between serum PCT,BNP,CRP and cTnI levels,but the correlation was PCT(r=0.831)>BNP(r=0.456)>CRP(r=0.287).Results Conclusion cTnI and serum PCT,CRP,BNP are in the serum of the patients.With the exacerbation of sepsis patients,there will be more significant myocardial injury symptoms.