单磷酸腺苷激活的蛋白激酶(AMPK)调控机制的研究进展

Research Progresses of AMP-activated Protein Kinase(AMPK)Regulation Mechanism

代谢是细胞和有机体最基本、最重要的活动之一.细胞和有机体通过感应系统实时监测代谢过程中的物质和能量状态,并不断地通过错综复杂的代谢调控途径来维持其稳态.代谢调控一旦出现紊乱,机体代谢就会发生异变,从而导致如糖尿病、肥胖、心血管疾病乃至肿瘤等多种人类重大疾病的发生,并影响发育、生长、繁殖、衰老等生命过程.单磷酸腺苷激活的蛋白激酶(AMPK)作为在代谢调控中起核心作用的激酶,自其被发现以来一直是研究的热点.对AMPK调控机制的深入研究为揭示代谢性疾病的发生和发展机制、探索其治疗和预防的策略提供了重要的新思路.围绕近年来国内外AMPK研究领域取得的进展,重点阐述AMPK在体内的激活机制以及本课题组在该领域中的一系列重要成果.

Metabolism is one of the fundamental and vitally important activities for all the living cells and organisms.By means of developing multiple internal sensing systems,the organisms are able to continuously monitor their energy state during metabolic process and maintain the energy homeostasis through several intricate regulation pathways.In human bodies,the failure of metabolic process can result in many diseases,including diabetes,obesity,cardiovascular disorders and even cancers.AMP-activated protein kinase(AMPK)is one of the master controllers of metabolism.Understanding the regulation mechanisms of AMPK can greatly allow us to reveal the development of metabolic diseases and explore relevant treatment strategies.This review will focus on some recent findings of the regulation of AMPK,as well as a series of important findings by our research group.