中国人GRIN2B、SNCA基因多态性与帕金森病相关幻觉的关联分析

The association analysis of GRIN2B、SNCA genetic polymorphisms with the susceptibility of hallucination in Chinese PD patients

目的探讨GRIN2B和SNCA基因多态性与不伴痴呆的帕金森病(PD)患者的幻觉症状是否相关。方法利用SNa Pshot SNP分型技术检测2个基因多态性,对53例幻觉组和47例无幻觉组及其两个亚组之间进行相关性分析。结果 GRIN2B和SNCA在PD有幻觉组和PD无幻觉组及其两个亚组的等位基因和基因型频率不存在显著差异。校正临床相关因素后,GRIN2B rs7301328的GG基因型降低PD相关幻觉发生风险(Recessive:OR’=0.246,95%CI[0.071~0.848],P’=0.026;Additive:OR’=0.432,95%CI[0.208~0.895],P’=0.024)。SNCA rs894278的GG基因型增加早发型PD幻觉发生的风险(Recessive:OR’=8.281,95%CI[1.217~56.334],P’=0.031)。未发现与PD幻觉迟发型的幻觉风险增加相关的基因多态性。结论在中国人不伴痴呆的PD人群中,GRIN2B rs7301328的GG基因型可能是PD相关幻觉的保护因素。而SNCA rs894278的GG基因型可能是PD患者幻觉早发型的幻觉发生的危险因素。

Objective To investigate GRIN2B and SNCA gene polymorphisms are whether related to hallucinations symptoms in Chinese Parkinson’s disease patients without dementia.Methods Use SNaPshot SNP genotyping to detecte two polymorphisms,correlation analysis was performed between the hallucinatory group of 53 patients and 47 non-hallucinogenic groups and two subgroups.Results There were no significant differences in GRIN2B and SNCA alleles and genotype frequencies of PD-hallucination and PD non-hallucination group,also of two subgroups with the control groups.After adjusting for the clinical factors,GG genotype of GRIN2B rs7301328 reduced the risk of the occurrence of PD-related hallucinations(Recessive:OR’=0.246,95%CI[0.071～0.848],P’=0.026;Additive:OR’=0.432,95%CI[0.208～0.895],P’=0.024).GG genotype of SNCA rs894278 increased the risk of the occurrence of early-onset hallucinations in PD(Recessive:OR’=8.281,95%CI[1.217～56.334],P’=0.031).No polymorphism is found to be associate with increased late-onset hallucinations risk.Conclusion Idiopathic Parkinson’s patients without dementia in the Chinese population,the GG genotype of GRIN2B gene may be a protective factor for the hallucination symptom of PD.But the GG genotype of SNCA gene may be a risk factor for early-onset hallucinations in PD patients.