左旋甲状腺素片和甲状腺片治疗甲状腺结节的效果及安全性对比

Comparison of the Efficacy and Safety of L-thyroxine and Thyroid Tablets in Treatment of Thyroid Nodules

目的:探讨并对比左旋甲状腺素片和甲状腺片治疗甲状腺结节的效果及安全性。方法:选取2015年9月-2016年11月在本院接受治疗的甲状腺结节患者92例,按照治疗方式的不同将其分为观察组和对照组,每组各46例。对照组采用甲状腺片治疗,观察组采用左旋甲状腺素片治疗,两组治疗时间均为6个月,观察记录两组患者的各项临床指标,包括治疗效果、游离三碘甲状腺原氨酸(FT_3)水平、游离甲状腺素(FT_4)水平、促甲状腺激素(TSH)水平和不良反应的发生情况等。结果:观察组治疗总有效率明显高于对照组,比较差异有统计学意义(P<0.05);两组患者治疗后结节直径均小于治疗前,且观察组患者治疗后结节直径小于对照组(P<0.05);治疗后,观察组FT_3和FT_4水平均高于对照组,且两组FT_3和FT_4水平均高于治疗前,比较差异均有统计学意义(P<0.05);治疗后,观察组TSH水平低于对照组,且两组TSH水平均低于治疗前,比较差异均有统计学意义(P<0.05);观察组不良反应发生率明显低于对照组,比较差异有统计学意义(P<0.05)。结论:与甲状腺片相比,应用左旋甲状腺素片治疗甲状腺结节能够取得更好的疗效,患者结节减小的更显著,激素水平也得到更有效调整,且不良反应发生更少,安全性更高,值得在临床推广应用。

Objective:To investigate and compare the efficacy and safety of L-thyroxine and Thyroid Tablets in treatment of thyroid nodules.Method:92 cases of thyroid nodules were treated in our hospital from September 2015 to November 2016 were selected,according to the different treatment methods,they were divided into observation group and control group,46 cases in each group.The control group was Treated with Thyroid tablets,and observation group was treated with L-thyroxine,they were treated for 6 months.The clinical parameters of the two groups were observed and recorded,including the therapeutic effect,free triiodothyronine(FT3)levels,free thyroxine(FT4)levels,thyroid stimulating hormone(TSH)levels and the incidence of adverse reactions.Result:The total effective rate of observation group was significantly higher than that of control group,the difference was statistically significant(P<0.05).The diameter of nodules in two groups after treatment were smaller than those before treatment,and the diameter of nodules in observation group after treatment was smaller than that of control group(P<0.05).After treatment,the levels of FT3 and FT4 in observation group were higher than those of control group,and the levels of FT3 and FT4 in two groups were higher than those of before treatment,the differences were statistically significant(P<0.05).After treatment,the level of TSH in observation group was lower than that of control group,and the level of TSH in two groups were lower than those of before treatment,the differences were statistically significant(P<0.05).The incidence of adverse reactions in observation group was significantly lower than that of control group,the difference was statistically significant(P<0.05).Conclusion:Compared with Thyroid Tablets,the application effect of L-thyroxine treatment of thyroid nodules can get better,more significant decrease of patients with nodular,hormone levels have been more effective adjustment,and less adverse reaction,high safety,it is worthy of clinical application