疱疹性咽峡炎与G6PD缺陷的关系

Relationship between Herpangina and G6PD Deficiency

目的:探讨葡萄糖-6-磷酸脱氢酶(glucose-6-phosphate dehydrogenase,G6PD)与疱疹性咽峡炎的关系,分析可能的机制。方法:选取本院2016年6月-2017年5月确诊为疱疹性咽峡炎患儿60例为观察组,同期体检的62例健康儿童为对照组。用全自动生化仪测定血液中G6PD值,观察记录观察组患儿G6PD活性正常组与缺乏组的总热程、心肌酶异常情况、住院天数。结果:观察组G6PD缺陷比例明显高于对照组(P<0.01)。观察组G6PD缺乏患儿总热程、心肌酶异常情况及住院天数均较G6PD正常者长,比较差异均有统计学意义(P<0.05)。结论:G6PD缺陷增加疱疹性咽峡炎的易感性,伴有G6PD缺乏的患儿病情更严重,其原因可能与氧化应激有关。

Objective:To study the relationship between glucose-6-phosphate dehydrogenase(G6PD)deficiency and Herpangina,analyze the possible mechanisms.Method:A total of 60 children with herpangina were collected from June 2016 to May 2017 in our hospital as the observation group,and 62 healthy children in the same period were selected as the control group.Determination of the activity of G6PD in blood by automatic biochemical analyzer,the total heat course,abnormal myocardial enzyme and hospitalization days of G6PD activity in normal group and deficient group were observed and recorded.Result:The percentage of G6PD deficiency cases in observation group was apparently higher than the control group(P<0.01).In observation group,the total heat,abnormal myocardial enzyme and hospitalization days of G6PD activity in deficient group were higher than normal group,the differences were statistically significant(P<0.05).Conclusion:G6PD deficiency fortifies susceptibility of Herpangina and aggravate the patients’condition.Its mechanism might be related to oxidative stress.