肠内营养联合GP方案对非小细胞肺癌患者营养状态及免疫功能的影响

Effect of Enteral Nutrition Combined with GP Regimen on Nutritional Status and Immune Function in Patients with Non-small Cell Lung Cancer

目的:探究肠内营养联合GP方案对非小细胞肺癌(NSCLC)患者营养状态及免疫功能的影响,为改善患者的营养状态及免疫功能提供参考。方法:选取2016年1-12月本院NSCLC患者101例作为研究对象,按照随机数字表法将其分为对照组50例和观察组51例,对照组采用GP方案进行治疗,观察组在对照组基础上联合肠内营养进行治疗。观察比较两组的临床疗效、营养状况以及免疫功能情况。结果:治疗后,观察组有效率为74.51%,对照组为70.00%,比较差异无统计学意义(P>0.05);治疗前,观察组血红蛋白、白蛋白及血清总蛋白水平分别为(107.23±13.14)、(31.24±3.02)、(61.12±5.23)g/L,对照组分别为(107.03±13.08)、(31.35±2.78)、(60.07±4.57)g/L,两组比较差异均无统计学意义(P>0.05);治疗后,观察组血红蛋白、白蛋白及血清总蛋白水平分别为(117.26±15.47)、(39.67±2.96)、(73.89±6.13)g/L,对照组分别为(108.24±14.17)、(32.33±3.65)、(65.47±5.31)g/L,两组比较差异均有统计学意义(P<0.05);治疗前,观察组CD3+、CD4+、CD8+、CD4+/CD8+水平分别为(50.67±6.53)、(31.28±3.01)、(21.32±4.56)、(1.23±0.05),对照组分别为(51.35±5.35)、(31.35±3.04)、(22.15±5.04)、(1.24±0.06),两组比较差异均无统计学意义(P>0.05);治疗后,观察组CD3+、CD4+、CD8+、CD4+/CD8+水平分别为(60.02±6.34)、(42.28±4.41)、(30.45±6.07)、(1.93±0.16),对照组分别为(53.68±4.53)、(34.72±3.67)、(23.62±5.34)、(1.37±0.16),两组比较差异均有统计学意义(P<0.05)。结论:肠内营养联合GP方案能有效减轻患者症状、缓解痛苦,改善患者的营养状态及免疫功能,提高患者的生命质量和生存率,对相关研究具有参考价值。

Objective:To explore effect of enteral nutrition combined with GP regimen on nutritional status and immune function in patients with non-small cell lung cancer,to provide a reference for improving patients’nutritional status and immune function.Method:101 patients with NSCLC in our hospital from Jan to Dec 2016 were selected as research objects,according to the random number table method,they were divided into control group of 50 cases and observation group of 51 cases.The control group was treated with GP scheme,and observation group was treated with enteral nutrition on basis of control group.The clinical efficacy,nutritional status and immune function between two groups were observed and compared.Result:After treatment,the effective rate of observation group was 74.51%,and control group was 70.00%,the difference was not statistically significant(P>0.05).Before treatment,the levels of hemoglobin,albumin and serum total protein in observation group were(107.23±13.14),(31.24±3.02),(61.12±5.23)g/L,and control group were(107.03±13.08),(31.35±2.78),(60.07±4.57)g/L,the differences were not statistically significant(P>0.05),after treatment,the levels of hemoglobin,albumin and serum total protein in observation group were(117.26±15.47),(39.67±2.96),(73.89±6.13)g/L,and control group were(108.24±14.17),(32.33±3.65),(65.47±5.31)g/L,the differences were statistically significant(P<0.05).Before treatment,the levels of CD3+,CD4+,CD8+,CD4+/CD8+in observation group were(50.67±6.53),(31.28±3.01),(21.32±4.56)and(1.23±0.05),and control group were(51.35±5.35),(31.35±3.04),(22.15±5.04)and(1.24±0.06),the differences were not statistically significant(P>0.05),after treatment,the levels of CD3+,CD4+,CD8+,CD4+/CD8+in observation group were(60.02±6.34),(42.28±4.41),(30.45±6.07),(1.93±0.16),and control group were(53.68±4.53),(34.72±3.67),(23.62±5.34),(1.37±0.16),the differences were statistically significant(P<0.05).Conclusion:Enteral nutrition combined with GP can effectively relieve the symptoms,relieve pain,improve the nutritional status and immune function of patients,improve the quality of life and survival rate of patients,and have reference value for related research.