老年尿毒症患者C反应蛋白的水平变化及其意义

Changes of C-reactive Protein in Elderly Uremic Patients and Its Significance

目的:探讨老年尿毒症患者C反应蛋白(CRP)的水平变化及其意义。方法:选取173例血液透析治疗3个月以上尿毒症患者,按年龄将其分为老年组(年龄≥60岁)和非老年组(年龄<60岁),均检测其外周血CRP,血清白蛋白(ALB)及血红蛋白(Hb),同时根据CRP水平将老年患者分为CRP正常组和CRP异常组,分析老年尿毒症血透患者CRP的变化情况及其与透析龄、贫血、营养不良等因素的关系。结果:老年组CRP水平明显高于非老年组(P<0.05),CRP正常组透析龄明显低于CRP异常组(P<0.05),CRP正常组Hb和ALB水平均高于CRP异常组(P<0.05)。结论:老年尿毒症患者更容易发生炎症反应,透析龄可能是导致老年透析患者炎症反应的重要原因,炎症反应在老年尿毒症透析患者贫血和营养不良中发挥重要作用。

Objective:To explore the changes of C-reactive protein(CRP)in elderly uremic patients and its significance.Method:A total of 173 uremic patients with hemodialysis over 3 months were divided into the elderly group(aged≥60 years)and the non-elderly group(aged<60 years).Their serum CRP,ALB,Hb were detected.The eldely uemic patients were divided in CRP normal group(CRP<8 mg/L)and CRP abnormal group(CRP≥8 mg/L).The changes of CRP in the eldely uemic patients and the relations with dialysis ages,anemia and malnutrition were analyzed.Result:CRP levels in the eldely group were higher than those in the nonelderly group(P<0.05).The dialysis ages in CRP normal group were lower than those in CRP abnormal group(P<0.05).The levels of Hb and ALB were both higher in CRP normal group compared with CRP abnormal group(P<0.05).Conclusion:Imflammatory response is induced more easely in the eldely uemic patients.Dialysis ages may be an important cause of imflammatory response.Imflammatory response has an important role in the anemia and malnutrition of the eldely uemic dialysis patients.