斑蝥酸钠维生素B_6联合卡培他滨治疗晚期胃肠道肿瘤的疗效观察

The Effect Observation of Sodium Cantharidate Vitamin B_6 Combined with Capecitabine in the Treatment of Advanced Stomach and Colorectal Carcinoma

目的:观察斑蝥酸钠维生素B_6注射液(艾易舒)联合卡培他滨治疗晚期胃肠道肿瘤的客观效果及不良反应。方法:将84例晚期胃肠道肿瘤患者随机分为对照组和治疗组,各42例。对照组采用卡培他滨常规治疗,治疗组在对照组的基础上加用斑蝥酸钠维生素B_6注射液进行治疗。2个周期后评价近期疗效及不良反应。结果:治疗组总有效率为42.9%,高于对照组的21.4%,差异有统计学意义(P<0.05)。两组的不良反应发生情况比较,差异均有统计学意义(P<0.05)。结论:斑蝥酸钠维生素B_6注射液可增强胃肠道肿瘤患者的抗病能力,减轻化疗不良反应,提高卡培他滨治疗晚期胃肠道肿瘤的效果。

Objective:To observe the objective effect and adverse effects of Sodium Cantharidate Vitamin B6 Injection(Ai Yishu)combined with Capecitabine in the treatment of advanced stomach and colorectal carcinoma.Method:A total of 84 patients with advanced stomach and colorectal carcinoma were randomly divided into the control group and treatment group,42 cases in each group.The control group was treated with Capecitabine,the treatment group was treated with Capecitabine and Sodium Cantharidate Vitamin B6.The shortterm effects,clinical effect and adverse effects were evaluated after two courses.Result:The total effective rate in the treatment group was 42.9%,which was higher than 21.4%in the control group,the difference was statistically significant(P<0.05).There were significant differences in the incidence of adverse effects between the two groups(P<0.05).Conclusion:Cantharidin Sodium Vitamin B6 Injection can enhance the disease resistance of gastrointestinal cancer patients,reduce the adverse effects of chemotherapy,and improve the effect of Capecitabine in the treatment of advanced stomach and colorectal carcinoma.