复方丹参注射液辅助治疗小儿过敏性紫癜Meta分析

Meta-analysis of compound Danshen injection in adjuvant therapy of Henoch-Schonlein purpura in children

目的系统评价复方丹参注射液辅助治疗过敏性紫癜的临床疗效及安全性。方法计算机检索PubMed、WEB of SCIENCE、The Cochrane Library、CNKI、VIP、WanFangData,收集所有关于复方丹参注射液治疗过敏性紫癜的随机对照试验,检索时限为建库至2016年11月30日。两位研究者按纳入与排除标准筛选文献、提取资料,按Cochrane系统评价的方法评价纳入研究的质量,采用RevMan 5.3软件进行Meta分析。结果共纳入10项随机对照试验,共计768例患儿。结果显示,复方丹参注射液辅助治疗过敏性紫癜在总有效率、皮疹消退时间、关节症状缓解时间及消化道症状缓解时间等方面均优于常规治疗组,差异有统计学意义(P<0.05)。未报道复方丹参注射液治疗过敏性紫癜的严重不良反应。结论复方丹参注射液辅助治疗小儿过敏性紫癜疗效确切,无明显不良反应,值得临床推广。但纳入研究的文献质量低,其疗效需要高质量临床试验来验证。

Objective To evaluate the efficacy and safety of compound Danshen injection for Henoch Schonlein purpura(HSP).Methods Clinical randomized controlled trials(RCT)were collected by searching Pubmed,WEB of SCIENCE,the Cochrane Library,CNKI,VIP and Wanfang Data from their inception to November 30,2016.Two researchers screen the literatures and selected the data according to inclusion and exclusion criteria.The quality of included studies was assessed according to the criteria recommended Cochrane Collaboration.Meta analysis was performed by using RevMan 5.3 software.Results Ten trials(n=768)were included.The results of Meta analysis demonstrated that,the efficiency of compound Danshen injection adjuvant therapy for HSP was better,including the total effective rate,the time of erythra regression time,the relief time of clinical symptoms of joints and the relief time of clinical gastrointestinal symptoms(P<0.05);there were no serious adverse effects in the treatment.ConclusionCompared with routine treatment,compound Danshen injection therapy might be a better choice for HSP with more remarkable efficacy and few adverse effects.However,the quality of the included literature is low,so high quality clinical trials are needed to verify its effect.