锶取代羟基磷灰石的制备方法和生物学特征

Synthesis and biological properties of strontium-substituted hydroxyapatite

背景:羟基磷灰石是天然骨和牙齿的主要矿物成分,具有非免疫原性、骨诱导性的特点,适用于骨组织修复;锶元素与钙是同族碱金属,已有研究证明锶具有促进成骨细胞分化和抑制破骨细胞活性的双重效应。目的:概述锶取代羟基磷灰石的制备方法及其生物学性能评价。方法:由第一作者通过计算机检索1990至2017年Pub Med数据库收录的相关文献,检索词为"strontium;substituted;doped;containing;hydroxyapatite",并筛选搜到的文献,排除相关性差、内容陈旧及重复的文献。结果与结论:锶取代羟基磷灰石的制备方法包括液相法(水热法、酸碱中和法与溶胶凝胶法)和固相法(机械化学法);另外,锶取代羟基磷灰石涂层可通过电化学沉积法和微弧氧化法一步制作。锶元素的引入明显改变了羟基磷灰石的晶体尺寸、结晶度、溶解度及机械性能,提高了羟基磷灰石的生物相容性、促成骨作用及抑制破骨作用,但最合适的锶取代比例有赖进一步探索。此外,锶取代羟基磷灰石的免疫调节作用和病理条件下的促成骨性能等方面的研究仍需进一步完善。

BACKGROUND:Hydroxyapatite is the main mineral component of bone and teeth.It is non-immunogenic and osteoinductive and suitable for bone repair.Strontium and calcium are cognate elements in the periodic table of elements and it has been proved that strontium has dual effects,namely,osteogenic promotion and suppression of osteoclast activity.OBJECTIVE:To summarize the preparation of strontium-substituted hydroxyapatite and its biological properties.METHODS:The first author searched the PubMed database for related literature from 1990 to 2017.The key words were"strontium;substituted;doped;containing;hydroxyapatite".The literatures obtained were screened,and the irrelevant and repetitive literatures were excluded.RESULTS AND CONCLUSION:The preparation methods of strontium-substituted hydroxyapatite include liquid-phase method(hydrothermal method,acid-base neutralization and sol-gel method)and solid-phase method(mechanochemical method).In addition,strontium-substituted hydroxyapatite coating can be produced by electrochemical deposition and micro-arc oxidation.The introduction of strontium significantly modifies the crystal size,crystallinity,solubility and mechanical properties,and improves the biocompatibility,pro-osteogenesis and osteoclast inhibition of hydroxyapatite,but the optimal proportion of strontium needs to be further explored.Furthermore,the immune-regulation and osteogenic properties under pathological conditions of strontium-substituted hydroxyapatite need to be further improved.