头孢克肟联合盐酸氨溴索对老年社区获得性肺炎患者血清指标的影响

The efficacy and safety of Cefminox combined with Ambroxol hydrochloride in the treatment of senile community acquired pneumonia

目的探究头孢克肟联合盐酸氨溴索对老年社区获得性肺炎患者PCT、CRP、NT-pro BNP、c Tn T-hs水平的影响,并分析临床疗效及安全性。方法 108例老年社区获得性肺炎患者随机分为对照组54例与试验组54例,两组均给予常规治疗以及对症治疗,对照组给予头孢克肟干混悬剂100 mg静脉滴注,2次/d,试验组在对照组的基础上给予盐酸氨溴索注射液30 mg静脉滴注,2次/d。2组患者1个周期均为7 d,共治疗1个周期。比较两组临床疗效、治疗前后血清降钙素原(PCT)、C反应蛋白(CRP)、氨基末端脑钠肽前体(NT-pro BNP)、高敏肌钙蛋白T(c Tn T-hs)水平以及不良反应发生情况。结果治疗后,对照组临床总有效率为81.48%,显著低于试验组的96.30%(P<0.05)。两组治疗后血清PCT、CRP、cTn T-hs、NT-proBNP水平均显著降低,且试验组显著小于对照组(P<0.05)。对照组不良反应发生率为12.96%,试验组为6.12%,差异无统计学意义(P>0.05)。结论头孢克肟联合盐酸氨溴索治疗老年社区获得性肺炎的临床疗效显著,安全性高。

Objective To evaluate the efficacy and safety of Cefminox combined with Ambroxol hydrochloride in the treatment of senile community acquired pneumonia.Methods A total of 108 cases with senile community acquired pneumonia included in this study were dividing into control group and treatment group with each 54 cases.The patients in the both groups were give regular treatment.Patients in the control group were given Cefminox 100mg iv,bid,and patients in the treatment group revieved Cefminox 100mg iv,bid,and Ambroxol hydrochloride 30mg,iv,bid,7 days for a course and treated for 1 course.The serum PCT,CRP,NT-proBNP,cTnT-hs and adverse drug reactions were compared between the two groups.Results The clinical efficacy in treatment group was 96.30%,which significant higher than that in control group(81.48%)(P<0.05).The serum levels of PCT,CRP,NT-proBNP and cTnT-hs were all decreased after treatment.And the levels of PCT,CRP,NT-proBNP and cTnT-hs in treatment group were much lower than those in the control group(P<0.05).The adverse drug reactions were not statistically different between the two groups(P>0.05).Conclusion Cefminox combined with Ambroxol hydrochloride in the treatment of senile community acquired pneumonia is effective with high safety.