MSCT全肿瘤灌注参数与结直肠癌临床病理分期及MVD、EGFR水平的相关性分析

Correlation Analysis of MSCT Whole Tumor Perfusion Parameters with Clinicopathologic Stage and MVDD and EGFR Levels in Colorectal Cancer

目的:探讨多层螺旋CT(MSCT)全肿瘤灌注参数与结直肠癌临床病理分期及肿瘤微血管密度(MVD)、表皮生长因子受体(EGFR)表达水平的相关性。方法:选取2014-2017年在本院就诊且进行MSCT全肿瘤灌注的42例结直肠癌患者为研究对象,记录患者灌注参数[血容量(BV)、血流量(BF)、达峰时间(TTP)、表面通透性(PS)],根据病理诊断结果患者进行临床病理分期,并按照免疫组化步骤检测肿瘤样本中MVD及EGFR表达情况,采用Person相关性分析或Spearman相关性分析检测灌注参数与其他指标的相关性。结果:根据病理结果,TNMⅠ期6例、Ⅱ期7例、Ⅲ期14例、Ⅳ期15例;且TNM分期与BF、TTP、PS均具有一定相关性(r_(BF)=-0.683,P=0.023;r_(TTP)=0.632,P=0.035;r_(PS)=0.654,P=0.035);此外MVD及EGFR与以上各参数均无明显相关性(P>0.05),但MVD与EGFR之间存在一定相关性(r=0.433,P=0.043),同时EGFR阴性组与阳性组BF、TTS表达比较,差异均有统计学意义(P<0.05)。结论:MSCT全肿瘤灌注参数与临床病理分期具有较好的相关性,而MVD及EGFR的相关性较差,因而较适宜作为临床病理特征分析的辅助指标。

Objective:To investigate the relationship between the perfusion parameters of multislice CT(MSCT)and clinical stage,colorectal cancer,microvessel density(MVD)and epidermal growth factor receptor(EGFR)expression in colorectal cancer.Method:From 2014 to 2017,42 patients with colorectal cancer treated with MSCT whole tumor perfusion were selected as study subjects.The perfusion parameters[blood volume(BV),blood flow(BF),peak to time(TTP)and surface permeability(PS)]were recorded.The expression of MVD and EGFR in tumor samples were detected according to the immunohistochemical method.The correlation between perfusion parameters and other indexes were analyzed by Person correlation analysis or Spearman correlation analysis.Result:According to the pathological results,there were 6 cases in TNM stageⅠ,7 cases in TNM stageⅡ,14 cases in TNM stageⅢand 15 cases in TNM stageⅣ.There was a certain correlation between TNM stage and BF,TTP,PS(rBF=-0.683,P=0.023;rTTP=0.632,P=0.035;rPS=0.654,P=0.035),in addition,there was no significant correlation between MVD and EGFR with the above parameters(P>0.05),but there was a correlation between MVD and EGFR(r=0.433,P=0.043).Meanwhile,the difference between EGFR negative group and positive group was statistically significant(P<0.05).Conclusion:The correlation between MSCT whole tumor perfusion and clinicopathologic stage is better than that between MVD and EGFR,so MVD and EGFR are more suitable for an auxiliary index for clinical pathological analysis.