摘要
microRNA(miRNA)是一类小非编码RNA,在基因表达过程中,通过与靶基因m RNA的3’非编码区结合,从而在转录后调控靶基因表达,miRNA可以调节多达30%的人类基因和控制多种细胞的代谢活动。有研究表明,miRNA在心血管疾病中有重要的调节作用,且miRNA可能成为心血管疾病的重要的生物标记物和药物靶点。急性冠脉综合征(ACS)是心血管疾病中的常见病,本文就miRNA在急性冠脉综合征中的作用做一综述。
microRNA(miRNA)is a class of small non-coding mRNAs that exert their posttranscriptional regulatory effects by targeting 3’untranslated region(3’UTR)of corresponding miRNA.It has been estimated that miRNA may regulate up to 30%of human genes and control various cellular processes.Previous studies have suggested that miRNA may play an important role during cardiovascular disease progression.Acute coronary syndrome(ACS)is a common disease in cardiovascular disease,this article described the role of miRNA in acute coronary syndrome.
作者
袁平
梁岩
田镭钢
饶绍奇
YUAN Ping;LIANG Yan;TIAN Leigang;RAO Shaoqi(Graduate Department,Guangdong Medical University,Zhanjiang 524000,China)
出处
《中国医学创新》
CAS
2018年第8期144-148,共5页
Medical Innovation of China
