妊娠期糖尿病与肠道菌群关系的研究进展

Research progresses of the relationship between gestational diabetes mellitus and intestinal flora

肠道菌群指定居于人体肠道的微生物群体,数量巨大、种类繁多,与人类多种疾病的发病相关,受到医学界广泛关注。已有研究证实,肠道菌群丰度及多样性改变引起的肠道菌群失调参与糖尿病的发生发展。妊娠期糖尿病(gestational diabetes mellitus,GDM)是糖尿病的四种类型之一,是妊娠期常见的并发症。肠道菌群的改变也对GDM发病起重要作用。补充微生态调节剂可改善肠道菌群紊乱,这为探索GDM的防治提供了新靶点和新思路。

Intestinal flora is the microbiota located in the human intestines with a huge number and a wide variety,which has attracted extensive attention in the medical field because of its correlation to the pathogenesis of many human diseases.It has been demonstrated that the intestinal flora dysbiosis induced by the changes in the abundance and diversity is involved in the onset and development of diabetes.As one of the four types of diabetes mellitus,gestational diabetes mellitus(GDM)is a common complication during pregnancy,and the change of intestinal flora also plays an important role in the pathogenesis of GDM.Supplement of microecological modulator can improve the intestinal flora disorder,which provides new targets and new ideas for the prevention and treatment of GDM.