肾衰宁颗粒联合血液透析对尿毒症患者肾功能及全身炎症应激反应的影响

Effect of Shenshuaining granule combined with hemodialysis on renal function and systemic inflammatory stress response in patients with uremia

目的:研究肾衰宁颗粒联合血液透析对尿毒症患者肾功能及全身炎症应激反应的影响。方法:选择在北京市平谷区医院接受血液透析治疗的尿毒症患者并随机分为两组,对照组在血液透析过程中接受常规对症支持治疗,观察组在血液透析过程中接受常规对症支持联合肾衰宁颗粒治疗。治疗后45d、90d时,测定血清中肾功能指标、炎症反应指标及氧化应激反应指标的变化。结果:治疗后45d、90d时,观察组血清中SCr、BUN、CysC、β2-MG。E-sel、L-sel、sICAM-1、TGF-β1、TSP-1、AOPP、MDA、8-OHdG的含量均显著低于对照组,eGFR的水平以及SOD、GSH-Px的含量均显著高于对照组。结论:肾衰宁颗粒联合血液透析能够改善尿毒症患者的肾功能并抑制全身炎症应激反应的激活。

Objective:To study the effect of Shenshuaining granule combined with hemodialysis on renal function and systemic inflammatory stress response in patients with uremia.Methods:Patients with uremia who received hemodialysis in Beijing Pinggu Hospital between June 2014 and May 2017 were selected and randomly divided into two groups:control group received routine symptomatic and supportive treatment during hemodialysis,and observation group accepted routine symptomatic and supportive treatment combined with Shenshuaining granule therapy during hemodialysis.45d and 90d after treatment,the changes of renal function indexes,inflammatory response indexes and oxidative stress response indexes in serum were measured.Results:45d and 90d after treatment,serum SCr,BUN,CysC,β2 MG,E sel,L sel,sICAM 1,TGFβ1,TSP 1,AOPP,MDA and 8 OHdG contents of observation group were significantly lower than those of control group whereas eGFR levels as well as SOD and GSH Px contents were significantly higher than those of control group.Conclusion:Shenshuaining granule combined with hemodialysis can improve the renal function and inhibit the activation of systemic inflammatory stress response in patients with uremia.