高渗盐水+沙丁胺醇雾化吸入对毛细支气管炎患儿炎症应激反应的影响

Effect of inhalation of hypertonic saline combined with salbutamol aerosol inhalation on inflammatory stress response in children with bronchiolitis

目的:探讨高渗盐水+沙丁胺醇雾化吸入对毛细支气管炎患儿炎症应激反应的影响。方法:选择在本院接受治疗的毛细支气管炎患儿92例,随机分为对照组及研究组各46例。对照组接受生理盐水+沙丁胺醇雾化吸入治疗,研究组接受高渗盐水+沙丁胺醇雾化吸入治疗。对比两组不同时间点血清中炎症介质、氧化应激指标含量的差异。结果:T0时,两组血清中炎症介质及氧化应激指标含量的差异无统计学意义。T1、T2时,研究组血清中炎症介质IL-4、IL-6、IL-8、hs-CRP的含量低于对照组;血清中氧化应激指标AOPPs、LHP、MDA的含量低于对照组,CAT、SOD的含量高于对照组。结论:毛细支气管炎患儿接受高渗盐水+沙丁胺醇雾化吸入治疗,可更为有效的抑制患儿全身炎症及氧化应激反应,减轻病情。

Objective:To investigate the effect of inhalation of hypertonic saline and salbutamol aerosol inhalation on inflammatory stress response in children with bronchiolitis.Methods:92 children with bronchiolitis treated in the hospital between April 2015 and May 2017 were divided into control group(n=46)and study group(n=46)by random number table.Control group were treated with saline+salbutamol aerosol inhalation,and study group were treated with hypertonic saline+salbutamol aerosol inhalation.The differences in serum contents of inflammatory mediators and oxidative stress indexes were compared between the two groups at different points in time.Results:There was no statistically significant difference in the serum contents of inflammatory mediators and oxidative stress indexes between the two groups at T0.At T1 and T2,serum inflammatory mediators IL 4,IL 6,IL 8 and hs CRP contents of study group were lower than those of control group;serum oxidative stress indexes AOPPs,LHP and MDA contents were lower than those of control group whereas CAT and SOD contents were higher than those of control group.Conclusion:Hypertonic saline+salbutamol aerosol inhalation can be more effective in inhibiting systemic inflammatory response and oxidative stress response and relieving the illness in children with bronchiolitis.