葡萄糖酸锌辅助治疗小儿轮状病毒性肠炎腹泻的疗效分析

The efficacy of adjuvant zinc gluconate therapy for infantile rotavirus enteritis diarrhea

目的:研究葡萄糖酸锌辅助治疗小儿轮状病毒性肠炎腹泻的疗效。方法:选择2014年3月~2017年4月期间因轮状病毒性肠炎腹泻在宝鸡市中心医院儿科住院治疗的患儿作为研究对象,随机分为接受葡萄糖酸锌联合常规治疗的观察组、接受常规治疗的对照组。治疗前及治疗后10天,测定血清中炎症细胞因子、免疫球蛋白、补体含量,外周血中T细胞亚群的含量及粪便中肠道菌群的含量。结果:治疗后10天,两组血清中TNF-α、IL-1β、IL-8、sIL-2R、DAO、D-乳酸的含量以及外周血中CD8+的含量、粪便中大肠埃希菌的含量均低于治疗前,血清中C3、C4、IgA、IgG的含量以及外周血中CD3^+、CD4^+的含量以及粪便中双歧杆菌、乳酸杆菌的含量均高于治疗前(P<0.05),且观察组血清中TNF-α、IL-1β、IL-8、sIL-2R、DAO、D-乳酸的含量以及外周血中CD8^+的含量、粪便中大肠埃希菌的含量均低于对照组,血清中C3、C4、IgA、IgG的含量以及外周血中CD3^+、CD4^+的含量以及粪便中双歧杆菌、乳酸杆菌的含量均高于对照组(P<0.05)。结论:葡萄糖酸锌辅助治疗小儿轮状病毒性肠炎腹泻能够抑制炎症反应、改善免疫应答及肠黏膜屏障功能。

Objective:To study the efficacy of adjuvant zinc gluconate therapy for infantile rotavirus enteritis diarrhea.Methods:Children who were hospitalized in Baoji Central Hospital due to rotavirus enteritis diarrhea between March 2014 and April 2017 were selected as the research subjects and divided into the observation group who received zinc gluconate combined with conventional treatment and the control group who received conventional treatment.The contents of inflammatory cytokines,immunoglobulin and complement in serum,the contents of T cell subsets in peripheral blood and the contents of intestinal flora in feces were determined before treatment and after 10 days of treatment.Results:after 10 days of treatment,TNFα,IL 1β,IL 8,sIL 2R,DAO and D lactic acid contents in serum,CD8+contents in peripheral blood as well as E.coli contents in feces of both groups were lower than those before treatment whereas C3,C4,IgA and IgG contents in serum,CD3+and CD4+contents in peripheral blood as well as bifidobacterium and lactobacillus contents in feces were higher than those before treatment(P<0.05),and TNFα,IL 1β,IL 8,sIL 2R,DAO and D lactic acid contents in serum,CD8+content in peripheral blood as well as E.coli content in feces of observation group were lower than those of control group whereas C3,C4,IgA and IgG contents in serum,CD3+and CD4+contents in peripheral blood as well as bifidobacterium and lactobacillus contents in feces were higher than those of control group(P<0.05).Conclusion:Adjuvant zinc gluconate therapy for infantile rotavirus enteritis diarrhea can inhibit the inflammatory response and improve the immune response and intestinal mucosal barrier function.